1005402-54-9

Upstream product

• 75912-94-6 4-(3-chloropropoxy)benzoic acid ethyl ester 
• 765-38-8 (R)-(-)-2-methylpyrrolidine 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 1005402-55-0 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone 
• 1005404-19-2 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-3-pyridin-2-yl-butyric acid ethyl ester 

Relevant academic research and scientific papers

Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity

H3R structure-activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules wi

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.