75912-94-6

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 109-70-6 1.3-chlorobromopropane 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 74226-04-3 1-[3-(4-ethoxycarbonylphenoxy)propyl]imidazole 
• 111626-39-2 4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzoic acid ethyl ester hydrochloride 
• 1005402-54-9 4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-benzoic acid ethyl ester 
• 75912-95-7 4-<3-(1H-imidazol-1-yl)propoxy>benzoic acid 
• 685565-08-6 ethyl 4-(3-piperidin-1-ylpropoxy)benzoate 
• 100840-55-9 ethyl 4-(3-phthalimidopropoxy)benzoate 
• 1005402-55-0 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone 
• 1005404-19-2 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-3-pyridin-2-yl-butyric acid ethyl ester 
• 752202-08-7 4-[3-(1-piperidinyl)propyloxy]benzoyl chloride 
• 685565-42-8 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]indole 
• 685565-70-2 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]isoindoline 
• 685565-39-3 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]indoline 
• 787548-36-1 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-fluoroisoindoline 
• 685565-60-0 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-cyanoisoindoline 

Relevant academic research and scientific papers

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

To address the multifactorial nature of Alzheimer's Disease (AD), a multi-target-directed ligand approach was herein developed. As a follow-up of our previous studies, a small library of newly designed 2-arylbenzofuran derivatives was evaluated towards ch

Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity

H3R structure-activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules wi

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES

The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

SUBSTITUTED-4-THIAZOLIDINONE DERIVATIVES

Disclosed are novel substituted 4-thiazolidinone derivatives having cyclooxygenase and 5-lipoxygenase inhibiting properties and which are topical antiinflammatory agents for inflammed conditions of the skin

Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment

A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.

Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.