1005774-67-3Relevant academic research and scientific papers
Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones
Johnston, Karen A.,Allcock, Robert W.,Jiang, Zhong,Collier, Ian D.,Blakli, Haakon,Rosair, Georgina M.,Bailey, Patrick D.,Morgan, Keith M.,Kohno, Yasushi,Adams, David R.
, p. 175 - 186 (2008/09/20)
Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazinones. For the first time alkynyl heterocycles are also shown to be effective dipolarophiles for pyridine N-imine, and analogous compounds can be accessed directly in modest yields through the reaction of 6-(alkyn-1-yl)pyridazin-3-one derivatives. The Royal Society of Chemistry 2008.
