1005785-94-3Relevant academic research and scientific papers
Benzo Annulenes as Antiviral Agents
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, (2018/08/29)
The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, usi
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Terao, Yoshito,Suzuki, Hideo,Yoshikawa, Masato,Yashiro, Hiroaki,Takekawa, Shiro,Fujitani, Yasushi,Okada, Kengo,Inoue, Yoshihisa,Yamamoto, Yoshio,Nakagawa, Hideyuki,Yao, Shuhei,Kawamoto, Tomohiro,Uchikawa, Osamu
, p. 7326 - 7329 (2013/02/21)
Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range of therapeutic targets.
APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
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Page/Page column 40-41, (2009/12/28)
The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture com
