10058-44-3

Basic information

• Product Name: Ferric pyrophosphate
• Synonyms: IRON PYROPHOSPHATE HYDRATE;IRON(III) PYROPHOSPHATE TRIBASIC HYDRATE;FERRIC PYROPHOSPHATE;FERRIC PYROPHOSPHATE HYDRATE;FERRIC DIPHOSPHATE HYDRATE;diphosphoricacid,iron(3+)salt(3:4);diphosphoricacid,iron(3++)salt(3:4);pyrophosphoricacid,iron(3+)salt(3:4)
• CAS NO: 10058-44-3
• Molecular Formula: 4Fe*3O₇P₂
• Molecular Weight: 745.21
• EINECS: 233-190-0
• Product Categories: Inorganics;Food Additives
• Mol File: 10058-44-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /soluble crystals
• Storage Temp.: Store at RT.
• Solubility: Water
• Water Solubility: insoluble H2O, acetic acid; soluble mineral acids [MER06]
• Stability: Hygroscopic
• CAS DataBase Reference: Ferric pyrophosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Ferric pyrophosphate(10058-44-3)
• EPA Substance Registry System: Ferric pyrophosphate(10058-44-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 10058-44-3(Hazardous Substances Data)

Usage

Description

Iron, which is the chief constituent of Earth’s core, is the most abundant element in Earth as a whole (about 35 percent) . Ferric pyrophosphate is an iron replacement product, is a mixed-ligand iron complex in which iron (III) is bound to pyrophosphate and citrate. It is widely used to fortify cereal flours and infant cereals, dispersible ferric pyrophosphate is as well absorbed as ferrous sulfate in adults. pyrophosphate ions participate in the ion transfer processes. These ions, as chelating agents, would release iron from transferrin and form a ferric pyrophosphate complex, and that pyrophosphate alone has the ability to mediate iron exchange from transferring to ferritin. Ferric pyrophosphate citrate should only be added to the bicarbonate concentrate; do not add to acid concentrate mixtures. Ferric pyrophosphate citrate is not intended for use in patients receiving peritoneal dialysis; it has not been studied in patients receiving home hemodialysis.

Chemical Properties

Ferric pyrophosphate (iron(III)pyrophosphate, Fe4(P207)3*xH2O) is a tan or yellowish-white odorless powder or Soluble crystals. It is insoluble in water but is soluble in mineral acids. It is prepared by reacting sodium pyrophosphate with ferric citrate. Ferric pyrophosphate is an important kind of compounds insoluble in water and also poorly soluble in dilute acid. It does not modify organoleptic characteristics of foods because of its white colour and low reactivity, making it suitable for many difficult-to-fortify food vehicles, such as salt, cereals, infant formulas, and rice. It has been demonstrated to be an effective iron fortificant from efficacy studies. However, the poor solubility of ferric pyrophosphate in gastric juice limits its bioavailability, which furthemore reduces its nutritional value. The relative bioavailability value (RBV) of ferric pyrophosphate was reported to be only about 50% from human studies.

Uses

Different sources of media describe the Uses of 10058-44-3 differently. You can refer to the following data:
1. Iron(III) Pyrophosphate can be used as an iron supplement for people with iron deficiencies.
2. Food and Feed additives/Food additives
3. Ferric Pyrophosphate is a nutrient supplement, tan or yellowish white in color, prepared by reacting sodium pyrophosphate with ferric citrate. the ingredient may be used in infant formula. it is also termed iron (iii) pyrophosphate.

Preparation

Ferric pyrophosphate was prepared by adding sodium pyrophosphate solution to ferric chloride solution. 2Fe2(SO4)3+3Na4P2O7=Fe4(P2O7)3+6Na2SO4 The precipitate collected was washed and a ferric pyrophosphate suspension was dispersed with lecithin and other emulsifiers.

General Description

Ferric Phosphate is a tan or yellowish white odorless powder. It is insoluble in water and soluble in mineral acids. It can be prepared by reacting sodium pyrophosphate with ferric citrate. It shows good bioaccesibility.

Flammability and Explosibility

Nonflammable

Safety Profile

When heated to decomposition it emits very toxic fumes of POx.

InChI:InChI=1/4Fe.3H4O7P2/c;;;;3*1-8(2,3)7-9(4,5)6/h;;;;3*(H2,1,2,3)(H2,4,5,6)/q4*+2;;;/p-12

Synthetic route

iron(III) chloride + sodium pyrophosphate (124-43-6) → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In water pH=3; Product distribution / selectivity;
With SUNLECITHIN A In water pH=3; Product distribution / selectivity;

iron(III) phosphate (765207-04-3) + iron metaphosphate → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent, solid phase) Fe(PO3)3 and FePO4 were heated at 940°C for 72 h under O2, annealed for 15 d under vac. at 900°C;

iron(III) oxide + ammonium dihydrogen phosphate (7722-76-1) → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent) calcining (900°C);

phosphoric acid (86119-84-8, 7664-38-2) + ferric nitrate (7782-61-8) → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In water evapn. of soln. Fe(NO3)3 and H3PO4, annealing (400°C, N2 atmosphere, 24 h);

ammonium dihydrogen phosphate (7722-76-1) + Ammonium iron sulfate → ferric pyrophosphate (10058-44-3) + iron(III) phosphate (765207-04-3)

Conditions

Yield

With H2O2 In ethanol; water soln. of Fe(NH4)2(SO4)2*6H2O (pH 4.9) added at ambient temp. to stirred soln. of (NH4)H2PO4 in water-EtOH (1.5:1, v/v) in 1:1 vol. proportion; concd. soln. of H2O2 added; ppt. kept in contact with mother liquor for 30 min without stirring; ppt. collected on membrane filter; washed (H2O); dried at room temp. in air for 2 ds; calcined in air at 750°C for 10 h; monitored by X-ray diffraction;

4Fe(3+)*3P2O7(4-)*4H2O=Fe4(P2O7)3*4H2O → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent, solid phase) heated in Pt crucible under air at 900°C;

iron(III) phosphite * 9 H2O → ferric pyrophosphate (10058-44-3) + iron(II) phosphate + phosphan (7803-51-2)

Conditions	Yield
In neat (no solvent) calcination Fe2(HPO3)3*9H2O; generation of PH3 and formation of Fe4(P2O7)3 and Fe3(PO4)2 as residue;;

[(S)-C5H14N2][Fe4(C2O4)3(HPO4)2(H2O)2] + oxygen (80937-33-3) → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent) byproducts: Fe2O3, C5H12N2, H2O; thermal decomposition in flowing oxygen at 700 °C; detn. by powder XRD, TGA;

(C2H10N2)(2+)*3Fe(2+)*4HPO3(2-)=(C2H10N2)[Fe3(HPO3)4] → ferric pyrophosphate (10058-44-3) + iron(III) phosphate (765207-04-3) + iron(III) phosphate (765207-04-3)

Conditions	Yield
In neat (no solvent, solid phase) heating from room temp. up to 815°C; detd. by time-resolved X-ray thermal diffractometry in air;

ammonium iron(III) orthophosphate → ferric pyrophosphate (10058-44-3) + iron(III) polyphosphate

Conditions	Yield
In neat (no solvent, solid phase) NH4Fe(HPO4)2 heated to 900°C in air;

iron(III) phosphate hydrate + iron(III) polyphosphate → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent, solid phase) stoich. mixt. was heated for 12 h at 800°C, then 72 h at 940°C; obtained phosphates were pulverized; XRD;

iron(III) oxide + ammonium dihydrogen phosphate (7722-76-1) + iron(III) phosphate hydrate → ferric pyrophosphate (10058-44-3)

Conditions	Yield
In neat (no solvent, solid phase) mixt. was heated at 800°C in air for 12 h, then at 940°C in air for 24-48 h; XRD;

iron(III) phosphate (765207-04-3) → ferric pyrophosphate (10058-44-3)

Conditions	Yield
at 500℃; for 3h; Inert atmosphere;

ferric pyrophosphate (10058-44-3) + iron(III) phosphate (765207-04-3) + phosphoric acid (86119-84-8, 7664-38-2) → Fe(3+)*HP2O7(3-)*1.5H2O + oxonium iron(III) orthophosphate hydrate

Conditions	Yield
With H2O In water powdered FePO4 is added during 3-4 d to H3PO4 (85%); boiling under reflux; ppt. washed with distd. water for 3-4 d and then vac. dried; elem. anal.;

ferric pyrophosphate (10058-44-3) + sodium pyrophosphate (124-43-6) → sodium iron(III) pyrophosphate*99H2O

Conditions	Yield
with Fe4(P2O7)3 satd. soln. of Na4P2O7; evapn. in vacuum over H2SO4;
with Fe4(P2O7)3 satd. soln. of Na4P2O7; evapn. in vacuum over H2SO4;

ferric pyrophosphate (10058-44-3) + iron(II) pyrophosphate → triiron bis(diphosphate)

Conditions	Yield
In neat (no solvent, solid phase) mixt. annealed at 900°C for 3 days (gold containers placed in a evacuated silica tubes);

ferric pyrophosphate (10058-44-3) + iron(II) pyrophosphate → Fe7(16+)*4P2O7(4-)=Fe7(P2O7)4

Conditions	Yield
In neat (no solvent, solid phase) heating (vac., 900°C, ratio of Fe2P2O7/Fe4(P2O7)3 5:1, sealed tube, FeCl2 as mineralizer agent);

Upstream product

• 10421-48-4 Ferric nitrate 
• 13472-36-1 Sodium pyrophosphate decahydrate 
• 9003-05-8 Polyacrylamide 
• 7722-88-5 Tetrasodium pyrophosphate 
• 7705-08-0 Ferric chloride 

Downstream Products

• 10058-46-5 1,2,3-propanetricarboxylate, 2-hydroxy-, chloride, neodymium salt 
• 1005-85-2 3,3-PENTAMETHYLENE-2-PYRROLIDINONE 
• 10058-60-3 1-(9,10-dihydro-9,10-ethanoanthracen-11-ylmethoxy)-N,N-dimethylpropan-2-amine hydrochloride (1:1) 
• 10058-62-5 1-(9,10-dihydro-9,10-ethanoanthracen-11-ylmethyl)-4-(2-hydroxyethyl)-1,4-dimethylpiperazinediium diiodide 
• 10058-63-6 1-[2-(9,10-ethanoanthracen-9(10H)-yloxy)ethyl]pyrrolidine hydrochloride (1:1) 
• 10058-64-7 1-[2-(9,10-ethanoanthracen-9(10H)-yloxy)ethyl]piperidine hydrochloride (1:1) 
• 10058-66-9 tubercidin 5'-triphosphate 
• 100586-99-0 2-Quinoxalinamine,N-ethyl-1,2-dihydro-1-methyl-(9CI) 
• 100587-34-6 2-{[(2E)-3-thiophen-2-ylprop-2-enoyl]amino}benzoic acid 
• 100587-37-9 2-{[(2E)-3-thiophen-3-ylprop-2-enoyl]amino}benzoic acid 
• 100587-46-0 methyl 2-{[3-(2-thienyl)acryloyl]amino}benzoate 
• 100587-52-8 Norfloxacin Succinil 
• 100587-90-4 LANTHANUM ACETATE HYDRATE 
• 100587-91-5 SAMARIUM ACETATE HYDRATE 

Recommend Products

• 765207-04-3  iron(III) phosphate 
• 7722-76-1  ammonium dihydrogen phosphate 
• 86119-84-8  phosphoric acid 
• 7782-61-8  ferric nitrate 
• 7803-51-2  phosphan 
• 765207-04-3  iron(III) phosphate 
• 765207-04-3  iron(III) phosphate 
• 10124-31-9  ammonium dihydrogen phosphate 
• 80937-33-3  oxygen 
• 124-43-6  sodium pyrophosphate