100592-05-0Relevant articles and documents
Unconventional Reactivity with DABCO-Bis(sulfur dioxide): C–H Bond Sulfenylation of Imidazopyridines
Le Bescont, Julie,Breton-Patient, Chloé,Piguel, Sandrine
, p. 2101 - 2109 (2020)
This work highlights the unexpected and unprecedented outcome of the reactivity with DABCO-bis(sulfur dioxide). The use of this reagent led to the exclusive introduction of a sulfur atom on the C-3 position of imidazopyridines instead of a sulfone group.
Metal-free, Tf2NH-catalyzed 1, 6-conjugate addition of imidazopyridine to para-quinone methides: Easy access to C3-functionalized triarylmethane imidazopyridine
Khonde, Nilesh S.,Said, Madhukar S.,Sabane, Jagjivan K.,Gajbhiye, Jayant M.,Kumar, Pradeep
supporting information, (2021/10/30)
An inexpensive and commercially available Tf2NH-catalyzed 1,6-conjugate addition of imidazopyridine (IMPY) heterocycles to para-quinone methides (p-QMs) is reported. The present transformation provides a diverse class of C3-functionalized triarylmethanes heterocyclic derivatives of imidazopyridine. These metal-free transformations provided a very broad substrate scope of conjugate addition product with a high yield up to 97% within a short duration.
Imidazopyridine compound, pharmaceutical composition containing the same, and preparation method and application thereof (by machine translation)
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Paragraph 0062-0066; 0117-0121, (2020/05/01)
Specifically discloses a pharmaceutical composition containing the compound and a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate [1,2 - a] of the compound, and the preparation method, comprises the following steps of inhibiting, protein selectivity, drug effect strong STAT3 patent medicine, safety and the like, and the like . is particularly suitable for preventing and, or treating tumor growth and metastasis as well as pharmaceutical composition and pharmaceutical acceptable salt or pharmaceutically acceptable salt or pharmaceutically acceptable solvate of the compound in preparing STAT3 high-expression cell abnormal proliferation, form change and exercise function hyperthyroidism, and other related diseases / and are disclosed in the present invention. (by machine translation)
Copper-catalyzed c-h functionalization of pyridines and isoquinolines with vinyl azides: Synthesis of imidazo heterocycles
Donthiri, Ramachandra Reddy,Pappula, Venkatanarayana,Reddy, N. Naresh Kumar,Bairagi, Dipayan,Adimurthy, Subbarayappa
, p. 11277 - 11284 (2015/01/08)
Copper(I) iodide-catalyzed oxidative C(sp2)-H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic conditions is reported. Goo
Imidazopyridazines. XVIII. Syntheses and Central Nervous System Activities of Some 6-, 7- and 8-(Chloro and methoxy)imidazopyridine Analogues
Barlin, Gordon B.,Davies, Les P.,Harrison, Peter W.
, p. 1031 - 1038 (2007/10/02)
Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy)-6(7 and 8)-chloro- and 6(and 8)-methoxy-imidazopyridines.In tests of the ability of these compounds to displace diazepam from rat brain membrane, those with 6-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazopyridines and imidazopyridazines.
SYNTHESIS OF NEW HETEROCYCLIC PHENOLS: 8-HYDROXY-IMIDAZOPYRIDINE
Rydzkowski, R.,Blondeau, D.,Sliwa, H.
, p. 2571 - 2574 (2007/10/02)
Preparation of the unknown title compound has been achieved by condensation of 2-amino-3-hydroxy-pyridine with chloroacetaldehyde.Activation by the free phenolic hydroxyl allows preferential nitration of the pyridine ring, in marked contrast to the behavior of the related ethers which suffer electrophilic substitution on the imidazole moiety, as usual in the series.
