100592-97-0

Usage

Uses

Used in Pharmaceutical Industry:
(Z)-1-acetyl-3-(4-methylbenzylidene)-2,5-piperazinedione is used as a building block for the synthesis of various biologically active molecules. Its role in medicinal chemistry research is significant due to its potential as an inhibitor of certain enzymes, which can contribute to the treatment of various diseases.
Used in Enzyme Inhibition:
(Z)-1-acetyl-3-(4-methylbenzylidene)-2,5-piperazinedione is used as an enzyme inhibitor for its potential to inhibit specific enzymes. This application is valuable in the development of treatments for various diseases, as enzyme inhibition can help regulate biological processes and pathways.
Used in Material Development:
(Z)-1-acetyl-3-(4-methylbenzylidene)-2,5-piperazinedione is also studied for its potential role in the development of new materials. Its unique chemical properties may contribute to the creation of innovative materials with specific applications.
Used as a Dye Precursor:
Furthermore, (Z)-1-acetyl-3-(4-methylbenzylidene)-2,5-piperazinedione has been explored as a precursor for the development of new dyes. Its chemical structure and properties make it a promising candidate for the creation of novel dyes with potential applications in various industries.

Upstream product

• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 100593-04-2 (Z)-1-benzyl-6-(4-methylbenzylidene)-2,5-piperazinedione 
• 100593-12-2 (Z)-1-benzyl-4-(4-methoxybenzyl)-6-(4-methylbenzylidene)-2,5-piperazinedione 
• 100565-08-0 1-benzyl-6-methoxy-4-(4-methoxybenzyl)-6-(4-methylbenzyl)-2,5-piperazinedione 
• 100565-06-8 4-Benzyl-3-(bromo-p-tolyl-methyl)-3-methoxy-1-(4-methoxy-benzyl)-piperazine-2,5-dione 
• 117531-69-8 3-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidene]-6-[1-p-tolyl-meth-(E)-ylidene]-piperazine-2,5-dione 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1

We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited PAI-1 in vitro with an IC50 = 0.2 μM. The synthesis and SAR of these compounds are desc

Potassium Fluoride on Alumina: Condensation of 1,4-Diacetylpiperazine-2,5-dione with Aldehydes. Dry Condensation under Microwave Irradiation. Synthesis of Albonursin and Analogues

1,4-Diacetylpiperazine-2,5-dione (1) was condensated with aldehydes (2) with KF on alumina without solvent under microwaves or in at room temperature in the presence of DMF.The reaction was stereoselective and some natural products (4a-c) like albonursin (4c) were synthesized.

Conjugated Systems Derived from Piperazine-2,5-dione

The preparation of mono- and of symmetrical and unsymmetrical bis-ylidene derivatives of piperazine-2,5-dione is described.The uv-visible absorption of the products is correlated with acceptor/donor character of the substituents.

Oxidative Removal of N-(4-Methoxybenzyl) Group on 2,5-Piperazinedinones with Cerium(IV) Diammonium Nitrate

It was shown that N-(4-methoxybenzyl) group on 2,5-piperazinediones can be oxidatively removed with cerium(IV) diammonium nitrate under mild conditions, and the oxidative removal was performed in some model compounds which have several functional groups.