3027-05-2Relevant articles and documents
A highly substituted pyrazinophane generated from a quinoidal system: Via a cascade reaction
Anderson, Christopher L.,Garzón-Ruiz, Andrés,Liang, Jiatao,Liu, Yi,Navarro, Amparo,Nenon, David P.,Teat, Simon J.
, p. 4472 - 4475 (2020)
The generation of a highly-substituted [2.2](2,5)pyrazinophane via a cascade reaction is presented. The pyrazinophane product is formed via the dimerization of a member of the para-azaquinodimethane (p-AQM) family of conjugated quinoidal compounds - reactivity that sheds light on the nature of stability in p-AQMs. Additionally, the electronic and structural nature of this highly-strained ring system are characterized.
Phenotype-Guided Natural Products Discovery Using Cytological Profiling
Ochoa, Jessica L.,Bray, Walter M.,Lokey, R. Scott,Linington, Roger G.
, p. 2242 - 2248 (2015)
Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the im
Chiral 1,2,3-Triazolium Salt Catalyzed Asymmetric Mono- and Dialkylation of 2,5-Diketopiperazines with the Construction of Tetrasubstituted Carbon Centers
Yang, Ju-Song,Lu, Ka,Li, Chen-Xiao,Zhao, Zu-Hang,Zhang, Xiao-Ming,Zhang, Fu-Min,Tu, Yong-Qiang
supporting information, (2022/01/22)
Novel asymmetric mono- and dialkylation reactions of α-substituted 2,5-diketopiperazines catalyzed by new chiral spirocyclic-amide-derived triazolium organocatalysts have been developed, resulting in a range of enantioenriched 2,5-diketopiperazine derivatives containing one or two tetrasubstituted carbon stereocenters. The reactions feature high yields (up to 98%), and excellent cis-diastereo- and enantioselectivities (up to >20:1 dr, >99 % ee), and they provide a new asymmetric synthetic approach to important functionalized 2,5-diketopiperazine skeletons. Furthermore, a possible reaction mechanism was proposed based on both control experiments and extensive DFT calculations.
One pot synthesis of N-monoalkylated plinabulin derivatives via multicomponent protocol and their application as anticancer agents
Ganesher, Asha,Chaturvedi, Priyank,Karkara, Bidhu Bhusan,Chatterjee, Indranil,Datta, Dipak,Panda, Gautam
, (2021/01/12)
A chemical library of seventeen N-monoalkylated plinabulin derivatives was designed and synthesized in one pot with high atom economy, good yield and operational simplicity in site selective manner with Z-configuration at 3,6-positions (3Z,6Z) which have
The synthesis and biological activity of the 3-ferrocenylpropenamides derived from 5(4H)-oxazolones
Wieczorek-B?au?, Anna,B?au?, Andrzej,Rychlik, B?a?ej,Pla?uk, Damian
, (2021/09/08)
We described a synthesis of new 3-ferrocenylpropenamides prepared by oxazolone-ring opening reaction with various primary and secondary amines. The antiproliferative activities of the obtained compounds were screened on human tumor cell lines (HCT116, SW6