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1006-20-8

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1006-20-8 Usage

General Description

9-Methyl-6-thiopurine, also known as 6-methylthiopurine or 6-me-thioguanine, is a chemical compound that belongs to the class of purine analogs. It is a derivative of the natural purine base guanine and is often used as an antiviral and antineoplastic agent. 9-Methyl-6-thiopurine has been found to exhibit strong antiviral activity against herpes simplex virus (HSV) and cytomegalovirus (CMV) and is also used in the treatment of certain types of cancer, including acute myeloid leukemia and acute lymphoblastic leukemia. It functions by interfering with the synthesis of DNA and RNA, ultimately leading to the inhibition of cell growth and the destruction of cancerous cells. Due to its potent biological effects, 9-methyl-6-thiopurine is a valuable compound in the field of medicinal chemistry and pharmaceutical research.

Check Digit Verification of cas no

The CAS Registry Mumber 1006-20-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1006-20:
(6*1)+(5*0)+(4*0)+(3*6)+(2*2)+(1*0)=28
28 % 10 = 8
So 1006-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N4S/c1-10-3-9-4-5(10)7-2-8-6(4)11/h2-3H,1H3,(H,7,8,11)

1006-20-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-METHYL-6-THIOPURINE

1.2 Other means of identification

Product number -
Other names METHYL-6-MERCAPTOPURINE,9

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1006-20-8 SDS

1006-20-8Relevant articles and documents

Chemoselective Perfluoromethylation of Thio- And Selenoamides

Xu, Tao,Xu, Xianhong,Zhang, Jianyu

, (2020)

A chemo- and regioselective perfluoromethylation using thioamides/selenoamides (prepared one step from corresponding lactams) as starting materials has been discovered. The reaction demonstrated complementary chemoselectivity to the C-H trifluoromethylation of (hetero)arenes as well as remarkable functional group compatibility especially toward radical sensitive olefin-, alkyne-, and arylhalide-bearing substrates. The examples of perfluorothio-/selenolated drug molecules indicated application potential of this strategy in drug modification and drug-analogue preparation.

Thio- or seleno-amide compound and preparation method thereof

-

Paragraph 0030-0033, (2020/07/24)

The invention discloses a thio- or seleno-amide compound and a preparation method thereof. The preparation method comprises the following steps of dissolving a chlorinated aromatic heterocyclic compound 1 in an EtOH solution, adding 1.0-2.0 times of equivalent thiourea or selenourea, stirring at 50-120 DEG C for 1-8 hours, and reacting to obtain a compound 2, namely the required thio- or seleno-amide compound. Each step of the synthetic route can be amplified, the yield can reach 85 percent, the synthesized compound provides a medical intermediate for synthesizing purine derivatives containingSCF3 or SeCF3, the synthetic route provided by the invention brings a simpler and more effective way for synthesizing compounds with biological activity, the yield is high, large-scale preparation can be realized, and the application prospect is very wide.

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