52602-68-3

Basic information

• Product Name: 6-chloro-N-methyl-pyrimidine-4,5-diamine
• Synonyms: 4,5-Pyrimidinediamine, 6-chloro-N4-methyl-;6-chloro-N-methyl-pyrimidine-4,5-diamine;6-Chloro-N4-methyl-4,5-pyrimidinediamine;4-(Methylamino)-5-amino-6-chloropyrimidine;4-Chloro-5-amino-6-(methylamino)pyrimidine;5-Amino-6-chloro-4-(methylamino)pyrimidine;6-chloro-4-Methyl-4,5-dihydropyriMidine-4,5-diaMine
• CAS NO: 52602-68-3
• Molecular Formula: C₅H₇ClN₄
• Molecular Weight: 158.5889
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 52602-68-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 62℃
• Boiling Point: 328.2 °C at 760 mmHg
• Flash Point: 152.3 °C
• Appearance: /
• Density: 1.447
• Vapor Pressure: 0.000192mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-chloro-N-methyl-pyrimidine-4,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-N-methyl-pyrimidine-4,5-diamine(52602-68-3)
• EPA Substance Registry System: 6-chloro-N-methyl-pyrimidine-4,5-diamine(52602-68-3)

Safety Data

• Hazardous Substances Data: 52602-68-3(Hazardous Substances Data)

Usage

General Description

6-chloro-N-methyl-pyrimidine-4,5-diamine is a chemical compound with the molecular formula C5H7ClN4. It is an intermediate used in the synthesis of pharmaceutical compounds and agrochemicals. 6-chloro-N-methyl-pyrimidine-4,5-diamine is a pyrimidine derivative with a chlorine atom and a methyl group attached to the pyrimidine ring. It is utilized as a building block in the production of various pharmaceuticals, such as antiviral and antitumor drugs. The compound also has potential applications in the agrochemical industry for the development of new pesticides. Overall, 6-chloro-N-methyl-pyrimidine-4,5-diamine is an important chemical intermediate with versatile uses in the pharmaceutical and agrochemical sectors.

InChI:InChI=1/C5H7ClN4/c1-8-5-3(7)4(6)9-2-10-5/h2H,7H2,1H3,(H,8,9,10)

Upstream product

• 23126-82-1 6-chloro-N-methyl-5-nitropyrimidin-4-amine 
• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 74-89-5 methylamine 

Downstream Products

• 875-31-0 9-methylhypoxanthine 
• 100123-83-9 6-chloro-N⁴-methyl-5-(4-nitro-benzylidene)-pyrimidine-4,5-diyldiamine 
• 2346-74-9 6-chloro-9-methyl-9H-purine 
• 13784-17-3 5-amino-4-methylaminopyrimidine 
• 30720-73-1 6-amino-9-methyl-8-phenyl-9H-purine 
• 116588-66-0 6-chloro-9-methyl-8-phenyl-9H-purine 
• 868163-77-3 6-chloro-9-methyl-8-(4-hydroxyphenyl)-9H-purine 

Relevant articles and documents

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases

The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N6-position, respectively, is reported. The compounds were tested with radioligand binding studies showing, in some cases, a low

New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists

A new series of 9-methyladenines, bearing different bulky groups at the 8-position, were prepared and their affinity for the four human adenosine receptor subtypes were evaluated. All the synthesized compounds showed affinities at the A1, Asub

Novel 8-arylated purines as inhibitors of glycogen synthase kinase

A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit glycogen synthase kinase-3,with good selectivity over ten kinases. Molecular modeling studies indicated that the most active compounds (8a and 8e),adopt a planar conformation,close to the shape of AMPPNP in the crystal structure of GSK-3. These compounds are stabilized by hydrophobic contacts between the 8-aromatic group and the protein adenine pocket and by electrostatic contacts.