1006-29-7

Usage

Physical appearance

White to off-white solid This describes the color and form of 1H-Indazole-1-methanol, which is a solid with a white or slightly off-white hue.

Solubility

Slightly soluble in water 1H-Indazole-1-methanol has limited solubility in water, meaning it can dissolve to a small extent in an aqueous environment.

Importance as an intermediate

Synthesis of pharmaceutical compounds and other organic molecules 1H-Indazole-1-methanol serves as a crucial intermediate in the production of various pharmaceutical compounds and other organic molecules, making it a valuable chemical in the field of chemistry.

Industrial applications

Production of agrochemicals and dyes 1H-Indazole-1-methanol is used in the manufacturing of agrochemicals, such as pesticides and fertilizers, as well as dyes for various industries.

Versatile chemical structure and properties

Wide range of applications in various industries The adaptable chemical structure and properties of 1H-Indazole-1-methanol make it suitable for use in a diverse range of industries, contributing to its commercial value.

Upstream product

• 271-44-3 benzimidazole 
• 50-00-0 formaldehyd 

Relevant academic research and scientific papers

Study of the Structure of 1-Hydroxymethylindazole and 1-Hydroxymethylbenzotriazole by X-ray crystallography, Multinuclear NMR in Solution and DFT Calculations

1-Hydroxymethylindazole and 1-hydroxymethylbenzotriazole have been studied in solution by 1H, 13C and 15N NMR spectroscopy and the X-ray structure of the second compound determined. DFT and GIAO calculations have been used to discuss geometries, energies (comparatively with 2-substituted isomers) and NMR chemical shifts.

Reductive cleavage of aryl O-carbamates to phenols by the Schwartz reagent. Expedient link to the directed ortho metalation strategy?

A general, mild, and efficient method for the reductive cleavage of aryl O-carbamates to phenols, 1 → 2 using the Schwartz reagent is reported. The method is selective, tolerating a large number of functional groups; may be carried out by direct or by an economical in situ procedure; and, notably, establishes a synthetic connection to the directed ortho metalation strategy (Figure 1) allowing new entries into difficult to prepare contiguously substituted aromatics and heteroaromatics.

1H-INDAZOLES AS SYNTHETIC AUXILIARIES FOR THE SYNTHESIS OF SECONDARY AROMATIC AMINES

Methodology of alkylation of aromatic amines using 1H-indazoles as synthetic auxiliares is reported.

A SELECTIVE SYNTHESIS OF UNSYMMETRICAL 1,1'-METHYLENEBISDIAZOLES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS

1,1'-Methylenebisdiazoles Az1-CH2-Az2, Az1 and Az2 being two different diazoles, can be prepared selectively in three steps, through 1-hydroxymethyl- and 1-chloromethyldiazoles, by solid-liquid (S-L) phase transfer catalysis.