1h-Indazole-1-methanol

Base Information

• Chemical Name: 1h-Indazole-1-methanol
• CAS No.: 1006-29-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Nikkaji Number: J2.049.255D
• Mol file: 1006-29-7.mol

Synonyms:1h-indazole-1-methanol;1006-29-7;(1H-indazol-1-yl)methanol;1H-indazol-1-ylmethanol;Indazol-1-ylmethanol;1-hydroxymethylindazole;starbld0044936;SCHEMBL9934410;AKOS030231801;NS-01129;CS-0339992

Chemical Property of 1h-Indazole-1-methanol

Chemical Property:

• Melting Point: 110 - 112°C
• PSA: 38.05000
• LogP: 0.98610
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-Indazol-1-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=NN2CO

Technology Process of 1h-Indazole-1-methanol

There total 3 articles about 1h-Indazole-1-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzimidazole (271-44-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1-hydroxymethyl-1H-indazole (1006-29-7)

Guidance literature:

In water; acetic acid; Heating;

Reference yield: 43.0%

C10H11N3O → 1-hydroxymethyl-1H-indazole (1006-29-7)

Guidance literature:

With zirconocene dichloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol401547d

Reference yield:

→ 1-hydroxymethyl-1H-indazole (1006-29-7)

Guidance literature:

Indazol, Formaldehyd, wss. HCl (neben Bis--methan);

upstream raw materials:

benzimidazole

formaldehyd