100600-99-5

Basic information

• Product Name: (2R,3R)-8,9-Dichloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
• CAS NO: 100600-99-5
• Molecular Weight: 441.378
• Mol File: 100600-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R)-8,9-Dichloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-8,9-Dichloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(100600-99-5)
• EPA Substance Registry System: (2R,3R)-8,9-Dichloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one(100600-99-5)

Safety Data

• Hazardous Substances Data: 100600-99-5(Hazardous Substances Data)

Upstream product

• 6647-25-2 6-Amino-2,3-dichloro-benzenethiol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 100601-39-6 (2S,3S)-8,9-Dichloro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 25150-27-0 6,7-dichloro-1,3-benzothiazol-2-amine 

Relevant articles and documents

Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivatives and Their Vasodilating and Hypotensive Activities

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.