1006030-97-2Relevant academic research and scientific papers
An expeditious synthetic route to proteomimetic foldamers
Karekar, Vaibhav V.,Bhoge, Bapurao A.,Saraogi, Ishu
, p. 556 - 560 (2019/01/10)
α-Helix proteomimetics such as oligobenzamides have been shown to successfully inhibit a broad array of protein-protein interactions (PPIs) mediated by α-helices. Here we report the synthesis of a protected oligobenzamide intermediate, which can be selectively deprotected and alkylated with desired side chains to rapidly afford a library of α-helix proteomimetics.
Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction
Plante, Jeffrey P.,Burnley, Thomas,Malkova, Barbora,Webb, Michael E.,Warriner, Stuart L.,Edwards, Thomas A.,Wilson, Andrew J.
supporting information; experimental part, p. 5091 - 5093 (2009/12/08)
Oligobenzamide inhibitors of the p53-hDM2 protein-protein interaction are described. The Royal Society of Chemistry 2009.
Synthesis of functionalised aromatic oligamide rods
Plante, Jeffrey,Campbell, Fred,Malkova, Barbora,Kilner, Colin,Warriner, Stuart L.,Wilson, Andrew J.
, p. 138 - 146 (2008/09/20)
A current goal in synthetic chemistry is the design and synthesis of molecules that adopt well defined conformations - so called foldamers. In this manuscript we describe a modular approach for construction of rod shaped para-oligobenzamide molecules. Our approach permits regiospecific incorporation of side chains through a phenolic ether linkage on the scaffold; a feature that partly restricts the conformation of the rod through intramolecular hydrogen-bonding. The Royal Society of Chemistry 2008.
