1006037-04-2Relevant articles and documents
Scalable synthesis of a prostaglandin EP4 receptor antagonist
Gauvreau, Danny,Dolman, Sarah J.,Hughes, Greg,Oshea, Paul D.,Davies, Ian W.
supporting information; experimental part, p. 4078 - 4085 (2010/08/22)
The evolution of scalable, economically viable synthetic approaches to the potent and selective prostaglandin EP4 antagonist 1 is presented. The chromatography-free synthesis of multikilogram quantities of 1 using a seven-step sequence (six in the longest
PROCESS FOR MAKING INDOLE CYCLOPROPYL AMIDE DERIVATIVES
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Page/Page column 9; 14, (2010/11/05)
An efficient and economical process for synthesizing kilogram quantities of an indole cyclopropyl amide derivative of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. The process comprises the coupling of indolecarboxylic acid der
PROCESS FOR MAKING THIOPHENE CARBOXAMIDE DERIVATIVE
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Page/Page column 13-15, (2009/04/25)
The invention encompasses a process for making a thiophene carboxamide derivative, which is an EP4 antagonist useful for treating pain and inflammation.
THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS
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Page/Page column 71, (2008/06/13)
The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoi