1006044-27-4Relevant academic research and scientific papers
CYCLOPROPYLAMINES AS LSD1 INHIBITORS
-
Paragraph 0688; 0689, (2015/09/22)
The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
Synthesis of novel substituted 3,8,11-triazaspiro[5,6]dodecan-7-ones
Qin, Lan-Ying,Cole, Andrew G.,Metzger, Axel,Saionz, Kurt W.,Henderson, Ian
scheme or table, p. 849 - 852 (2011/03/20)
A synthesis of novel substituted 3,8,11-triazaspiro[5,6]dodecan-7-ones using a combination of solution-phase and solid-phase chemistries is described. A solution-phase approach was used to produce a key piperidine intermediate that was then incorporated into a solid-phase synthesis. The combined synthetic strategy was applied to provide a series of substituted 3,8,11-triazaspiro[5,6] dodecan-7-ones in good yield and high purity.
Certain Chemical Entities, Compositions and Methods
-
Page/Page column 14, (2009/10/30)
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
-
Page/Page column 119-120, (2008/06/13)
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
