100610-44-4Relevant articles and documents
Modular phosphine-aminophosphine ligands based on chiral 1,2,3,4-tetrahydro-1-naphthylamine backbone: A new class of practical ligands for enantioselective hydrogenations
Qiu, Min,Hu, Xiang-Ping,Huang, Jia-Di,Wang, Dao-Yong,Deng, Jun,Yu, Sai-Bo,Duan, Zheng-Chao,Zheng, Zhuo
experimental part, p. 2683 - 2689 (2009/10/14)
A series of new chiral phosphine-aminophosphine ligands [(R)-HW-Phos] has been prepared from (R)-1,2,3,4-tetrahydro-1-naphthylamine through a two-step procedure, and successfully applied in the rhodium-catalyzed asymmetric hydrogenation of various functionalized olefins such as α-enol ester phosphonates, α-enamido phosphonates, (Z)-β-(acylamino)acrylates and so on. Excellent enantioselectivities have been achieved in the hydrogenation of most substrates tested, demonstrating the high potential of these newly developed phosphine-aminophosphine ligands in asymmetric catalysis. The present research also discloses that these newly developed phosphine-aminophosphine ligands are more efficient than that derived from (S)-1-phenylethylamine, suggesting that the increased rigidity conferred by a cyclohexyl fragment in these phosphine-aminophosphine ligands has a positive effect in the asymmetric induction.
