100616-90-8Relevant academic research and scientific papers
O -iodoxybenzoic acid mediated oxidative desulfurization initiated domino reactions for synthesis of azoles
Chaudhari, Pramod S.,Pathare, Sagar P.,Akamanchi, Krishnacharaya G.
experimental part, p. 3716 - 3723 (2012/06/16)
A systematic exploration of thiophilic ability of o-iodoxybenzoic acid (IBX) for oxidative desulfurization to trigger domino reactions leading to new methodologies for synthesis of different azoles is described. A variety of highly substituted oxadiazoles, thiadiazoles, triazoles, and tetrazoles have been successfully synthesized in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthiourea, 1,3-disubtituted thiourea, and thioamides.
Three-component strategy toward 5-membered heterocycles from isocyanide dibromides.
Kaim, Laurent El,Grimaud, Laurence,Patil, Pravin
, p. 1261 - 1263 (2011/04/25)
A three-component strategy starting from isocyanides allows a straightforward synthesis of five-membered ring heterocycles. New cascades were developed involving the addition of a nitrogenated nucleophile-an azide or a tetrazole-on isocyanide dibromides,
Direct C-H arylation and alkenylation of 1-substituted tetrazoles: Phosphine as stabilizing factor
Spulak, Marcel,Lubojacky, Richard,Senel, Petr,Kunes, Jiri,Pour, Milan
experimental part, p. 241 - 244 (2010/04/06)
(Chemical Equation Presented) Direct arylation and alkenylation of 1-substituted tetrazoles was achieved via Pd catalysis in the presence of CuI and Cs2CO3. Unlike the related reactions of imidazoles and purines, phosphine ligand was
