100618-94-8

Basic information

• Product Name: Butanamide, 2,4-dihydroxy-3,3-dimethyl-N-(phenylmethyl)-
• CAS NO: 100618-94-8
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.299
• Mol File: 100618-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanamide, 2,4-dihydroxy-3,3-dimethyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2,4-dihydroxy-3,3-dimethyl-N-(phenylmethyl)-(100618-94-8)
• EPA Substance Registry System: Butanamide, 2,4-dihydroxy-3,3-dimethyl-N-(phenylmethyl)-(100618-94-8)

Safety Data

• Hazardous Substances Data: 100618-94-8(Hazardous Substances Data)

Upstream product

• 565430-86-6 2,4-dihydroxy-N-phenyl-3,3-dimethylbutyramide 
• 79-50-5 pantolactone 
• 43180-77-4 N-heptyl-2,4-dihydroxy-3,3-dimethylbutyramide 
• 4417-86-1 (R,S)-2,4-Dihydroxy-3,3-dimethylbutyramide 
• 100-46-9 benzylamine 

Downstream Products

• 565430-86-6 2,4-dihydroxy-N-phenyl-3,3-dimethylbutyramide 
• 79-50-5 pantolactone 
• 70006-37-0 rac-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone 
• 4417-86-1 (R,S)-2,4-Dihydroxy-3,3-dimethylbutyramide 
• 222609-34-9 1-benzyl-4,4-dimethylpyrrolidine-2,3,5-trione 

Relevant articles and documents

One-pot synthesis of N-substituted pantolactams from pantolactone

Rac-N-substituted pantolactams (5) are readily obtained in medium to good yields by reaction of rac-pantolactone (1) with primary amines under acid catalysis, whether at 250°C in a pressure reactor or under microwave irradiation. It appears that the amine can react with pantolactone at the carbonyl carbon atom to give a hydroxyamide (3) in a reversible way and at the methylene carbon atom to give a γ-amino acid (4). The last one on dehydration would give the corresponding pantolactam (5).