1006300-03-3

Upstream product

• 1006300-02-2 (3-bromo-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone 
• 96606-04-1 5-isopropyl-6-chloro-2,4-dimethoxypyrimidine 
• 871116-91-5 2-(3-bromo-5-methylphenyl)acetonitrile 

Downstream Products

• 1006300-82-8 N-{4-[6-(3-Bromo-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-pyridin-2-yl}-acetamide 
• 1006300-84-0 6-(3-bromo-5-methyl-benzoyl)-1-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione 
• 1006300-86-2 6-(3-bromo-5-methyl-benzoyl)-1-[2-chloro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione 
• 1097628-00-6 3-[[3-ethyl-1,2,3,6-tetrahydro-5-(1-methylethyl)-2,6-dioxo-4-pyrimidinyl]carbonyl]-5-methylbenzonitrile 
• 1006300-12-4 3-(5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-5-methyl-benzonitrile 

Relevant academic research and scientific papers

PROCESSES FOR PREPARING HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula (I): can be prepared by a multi-step process from compounds of Formula (II): wherein G is Cl, Br or I.

Novel HIV reverse transcriptase inhibitors

The invention is related to compounds of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.