1006377-63-4

Basic information

• Product Name: C₁₃H₁₉NO₅
• Synonyms: C₁₃H₁₉NO₅
• CAS NO: 1006377-63-4
• Molecular Weight: 269.298
• Mol File: 1006377-63-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₉NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₉NO₅(1006377-63-4)
• EPA Substance Registry System: C₁₃H₁₉NO₅(1006377-63-4)

Safety Data

• Hazardous Substances Data: 1006377-63-4(Hazardous Substances Data)

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 80407-64-3 3,4-bis(2-methoxyethoxy)benzaldehyde 

Downstream Products

• 80407-68-7 3,4-bis(2-methoxyethoxy)-benzonitrile 
• 183319-69-9 erlotinib hydrochloride 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 
• 236750-65-5 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile 
• 179688-29-0 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one 

Relevant articles and documents

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.

A PROCESS FOR SYNTHESIS OF [6,7-BIS-(2-METHOXYETHOXY)-QUINAZOLIN-4- YL]-(3-ETHYNYLPHENYL)AMINE HYDROCHLORIDE

A process for synthesizing [6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlitinib Hydrochloride) having the formula (I) comprising reacting 3,4-dihydroxy benzaldehyde with bromo derivative of ethyl methyl ether to obtain 3,4-bis(2-methoxyethoxy)benzaldehyde having formula (III). This is converted to give 3,4- bis (2-methoxyethoxy)-benzonitrile. On further nitration we obtain 4,5- bis (2-methoxyethoxy)-2-nitrobenzonitrile which on nitro reduction we get 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile and reacting this with N'-(3-ethynylphenyl)-N,N-dimethyl formamidine gives erlotinib free base. On further treatment of this free base with methanolic/ethanolic hydrochloric acid gives us erlotinib hydrochloride.