80407-68-7

Basic information

• Product Name: 3,4-Bis(2-methoxyethoxy)benzonitrile
• Synonyms: 3,4-Bis(2-methoxyethoxy)benzonitrile
• CAS NO: 80407-68-7
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251
• EINECS: 1308068-626-2
• Mol File: 80407-68-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 382℃
• Flash Point: 151℃
• Appearance: /
• Density: 1.12
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-Bis(2-methoxyethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Bis(2-methoxyethoxy)benzonitrile(80407-68-7)
• EPA Substance Registry System: 3,4-Bis(2-methoxyethoxy)benzonitrile(80407-68-7)

Safety Data

• Hazardous Substances Data: 80407-68-7(Hazardous Substances Data)

Usage

General Description

3,4-Bis(2-methoxyethoxy)benzonitrile is a chemical compound formed by the substitution of two hydroxyl groups of benzonitrile with two 2-methoxyethoxy groups. This results in a white powder with a molecular formula of C16H19NO4 and a molecular weight of 289.33 g/mol. It is primarily used as a raw material or intermediate in the production of other chemicals and pharmaceuticals. 3,4-Bis(2-methoxyethoxy)benzonitrile is also commonly used as a solvent and in organic synthesis due to its ability to dissolve a wide range of materials. Additionally, it has been studied for its potential applications in electrochemical devices and as an electrolyte additive due to its high stability and low volatility.

Upstream product

• 1006377-63-4 C₁₃H₁₉NO₅ 
• 80407-64-3 3,4-bis(2-methoxyethoxy)benzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1418289-91-4 3,4-bis(2-methoxyethoxy)-benzamide 
• 819813-71-3 3,4-bis(2-methoxyethoxy)-benzoic acid 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 627-42-9 2-chloroethyl methyl ether 
• 17345-61-8 3,4-dihydroxybenzonitrile 
• 121-33-5 vanillin 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 

Downstream Products

• 236750-65-5 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile 
• 950596-58-4 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile 
• 950596-59-5 N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine 
• 183321-74-6 erlotinib 
• 1172625-04-5 4,5-bis(2-methoxyethoxy)-2-nitrobenzamide 
• 236750-62-2 2-amino-4,5-bis[(2-methoxy)ethoxy]benzamide 
• 183319-69-9 erlotinib hydrochloride 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 
• 179688-29-0 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one 

Relevant articles and documents

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability. This journal is

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.

Br?nsted Acid Catalyzed Nitrile Synthesis from Aldehydes Using Oximes via Transoximation at Ambient Temperature

The Br?nsted acid-catalyzed synthesis of nitriles is described via transoximation under mild conditions using an O-protected oxime as a more stable equivalent of explosive O-protected hydroxylamines. The nitrile was generated via an O-protected aldoxime produced from the aldehyde and an O-protected oxime through transoximation. The reaction could be performed on a 1 g scale.