100644-67-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure and potential therapeutic properties make it a valuable component in the development of new medications for various health conditions.
Used in Cancer Treatment Research:
In the field of oncology, 4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is used as a research compound for studying its potential role in treating cancer. Its investigation as a kinase inhibitor highlights its possible application in the development of targeted cancer therapies.
Used in Cardiovascular Disease Research:
4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is also used in research aimed at understanding its potential impact on cardiovascular diseases. Its exploration in this area could lead to the discovery of new treatments for heart-related conditions.
Used in Neurological Disorder Research:
4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE is utilized in the study of neurological disorders, with the aim of identifying its potential therapeutic effects on conditions affecting the brain and nervous system. Its role in this research could contribute to advancements in the treatment of such disorders.
Used in Drug Discovery:
4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is used as a key component in drug discovery, where its properties and interactions with biological targets are explored to develop new pharmaceutical agents for various diseases. Its potential as a kinase inhibitor makes it a promising candidate for the creation of innovative therapeutics.

Upstream product

• 100644-65-3 4-chloro-6-aminopyrazolo[3,4-d]pyrimidine 
• 5604-46-6 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde 
• 124-41-4 sodium methylate 
• 100644-65-3 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine 

Downstream Products

• 109737-90-8 6-amino-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 100644-68-6 6-amino-1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-methoxy-1H-pyrazolo<3,4-d>pyrimidine 
• 203180-01-2 3-Iodo-4-methoxypyrazolo[3,4-d]pyrimidine-6-ylamine 
• 109737-94-2 6-Amino-2-(2'-deoxy-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 100644-70-0 8-aza-7-deaza-2'-deoxyguanosine 
• 117852-20-7 4-Methyl-benzoic acid (2R,3S,5R)-5-(6-amino-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl)-3-(imidazole-1-carbothioyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 117818-26-5 6-amino-1-<2'-deoxy-3'-O-(methoxythiocarbonyl)-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117818-24-3 6-amino-1-<2'-deoxy-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117818-22-1 6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 203180-05-6 6-Amino-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 203180-03-4 6-Amino-3-bromo-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 203180-01-2 6-amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

nitrogen hybridization guanine nucleoside and its synthetic method and the use of DNA sequencing

The invention discloses hybrid azaguanosine as well as a synthesis method and an application thereof in DNA sequencing. The synthesis method comprises the steps: removing a protecting group of a compound as shown in formula (III) in the specification under an alkaline condition to obtain a compound as shown in formula (II) in the specification; further demethylating to obtain a compound as shown in formula (I) in the specification, i.e. 7-deaza-7-halogen-8-aza-guanosine, wherein R1 is H or OH, R2 is I, Br or Cl, and R3 is H or a compound shown in the specification. The hybrid azaguanosine disclosed by the invention is a novel reagent for DNA sequencing, which, compared to guanosine failing to substitute nitrogen on 8 sites, is more excellent in base identifying effect and more stable in DNA chain structure. Meanwhile, different from the prior art that 8-site nitrogen-substituted guanosine is complex in synthesis method, low in yield and unsuitable for commercial production, the synthesis method disclosed by the invention is easily available in raw material required, and adopts conventional chemical synthesis reaction; and the method is relatively high in yield, and suitable for wide popularization and application.

Process for the synthesis of pyrazolopyrimidines

The present invention provides a nucleoside comprising a pyrazolopyrimidine base and a process for producing the same. In particular, the processes of the present invention comprises using a halogenated pyrazolopyrimidine base and removing the halogen after the base is coupled to a sugar moiety. The presence of the halogen on the nucleoside base allows facile and economical production of a large quantity of nucleosides.

SYNTHESIS OF THE β-D-DEOXYRIBOFURANOSIDE OF 6-AMINO-1H-PYRAZOLO-PYRIMIDIN -4(5H)-ONE - A NEW ISOSTER OF 2'-DEOXYGUANOSINE

6-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H-pyrazolopyrimidin-4(5H)-one (8) has been synthesized via regio- and diastereo-selective phase-transfer glycosylation of 6-amino-4-methoxy-1H-pyrazolopyrimidine (4) with 2-deoxy-3,5-di-O-(p-to