100649-38-5Relevant academic research and scientific papers
Nickel/Photoredox Dual Catalytic Cross-Coupling of Alkyl and Amidyl Radicals to Construct C(sp3)-N Bonds
Zhou, Shaofang,Lv, Kang,Fu, Rui,Zhu, Changlei,Bao, Xiaoguang
, p. 5026 - 5034 (2021/05/07)
The construction of C(sp3)-N bonds via direct radical-radical cross-coupling under benign conditions is a desirable but challenging approach. Herein, the cross-coupling of alkyl and amidyl radicals to build aliphatic C-N bonds in a concise, mild, and oxid
Syntheses of novel N-([ 18F]fluoroalkyl)-N-nitroso-4-methyl-benzenesulfonamides and decomposition studies of corresponding 19F- and bromoanalogues: Potential new compounds for the 18F-labelling of radiopharmaceuticals
Schirrmacher, Ralf,Mathiasch, Bernd,Schirrmacher, Esther,Radnic, Dragana,Roesch, Frank
, p. 959 - 977 (2007/10/03)
N-([18F]fluoroalkyl)-N-nitroso-4-methyl-benzensulfonamides [n-alkyl = (-CH2) [18,19F]F, n = 2-4)] were synthesized in radiochemical yields ranging from 75-90% to provide new secondary labelling precursors for the syntheses
Ring-closure Reactions. Part 23. Kinetics of Formation of Three- to Seven-membered-ring N-Tosylazacycloalkanes. The Role of Ring Strain in Small- and Common-sized-ring Formation
Martino, Alessandro Di,Galli, Carlo,Gargano, Patrizia,Mandolini, Luigi
, p. 1345 - 1350 (2007/10/02)
Rates of cyclisation of a series of anions derived from N-tosyl-ω-bromoalkylamines to nitrogen heterocycles with three to seven members in Me2SO-H2O (99:1) have been studied.Rates vary markedly with ring size in the order 5 > 3 > 6 > 7 ca. 4.First order rate constants for cyclisation have been translated into effective molarities (EM) with reference to an appropriate intermolecular model reaction.Comparison of the present results with available literature data on SN2 ring-closure reactions leading to small- and common-sized rings reveals that the ease of formation of three-membered rings is much more structure-dependent than that of the higher homologues.This remarkable behaviour is believed to parallel the unique way in which the stability of three-membered rings is affected by structure.As a rule, the ease of cyclisation appears to bear an inverted relationship to the assumed strain energy of the ring product.The apparent opposition of this rule to earlier conclusions in the literature is discussed.
