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6435-78-5

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6435-78-5 Usage

Description

1-[(4-methylphenyl)sulfonyl]pyrrolidine, also known as Lenalidomide, is a chemical compound that belongs to the class of immunomodulatory drugs. It is primarily used as a treatment for multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma. Lenalidomide works by stimulating the immune system to attack and destroy abnormal cells, and also has anti-inflammatory and anti-angiogenic properties. It is usually taken orally in the form of a capsule and is often used in combination with other medications for maximum effectiveness.

Uses

Used in Oncology:
Lenalidomide is used as an immunomodulatory drug for the treatment of multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma. It enhances the immune system's ability to target and destroy abnormal cells, making it a valuable treatment option for these conditions.
Used in Combination Therapy:
Lenalidomide is often used in combination with other medications to maximize its therapeutic effects. This approach can help improve patient outcomes and increase the effectiveness of treatment for various cancers.
Used in Anti-inflammatory and Anti-angiogenic Treatments:
Due to its anti-inflammatory and anti-angiogenic properties, Lenalidomide can also be used in the treatment of conditions that involve inflammation and abnormal blood vessel growth. This makes it a versatile drug with potential applications in various medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 6435-78-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,3 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6435-78:
(6*6)+(5*4)+(4*3)+(3*5)+(2*7)+(1*8)=105
105 % 10 = 5
So 6435-78-5 is a valid CAS Registry Number.

6435-78-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-cyclopentyl-p-toluenesulfonamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6435-78-5 SDS

6435-78-5Relevant articles and documents

Method for preparing N-sulfonyl tetrahydropyrrole compound by using gold complex

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Paragraph 0054-0059, (2021/07/17)

The invention relates to a method for preparing an N-sulfonyl tetrahydropyrrole compound by using a gold complex, which comprises the following step of: reacting a sulfonamide compound and a tetrahydrofuran compound as raw materials with a gold complex containing an ortho-carborane Schiff base ligand as a catalyst at room temperature to obtain the N-sulfonyl tetrahydropyrrole compound. Compared with the prior art, the method has the advantages that the gold complex containing the ortho-carborane Schiff base ligand is adopted as the catalyst, the sulfonamide compound and the tetrahydrofuran compound can be catalyzed to react under the room temperature condition to prepare the N-sulfonyl tetrahydropyrrole compound, the usage amount of the catalyst is low, the reaction condition is mild, the reaction rate is high, the product yield is high, the substrate is high in universality, the raw materials are cheap and easy to obtain, and the method has a wide application prospect in industry.

Synthesis method of aryl tertiary sulfonamide compounds promoted by visible light

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Paragraph 0021-0022, (2021/01/25)

The invention provides a synthesis method of aryl tertiary sulfonamide compounds promoted by visible light. In a non-protonic solvent, N-benzyl tertiary amine and arylsulfonyl chloride are used as rawmaterials, under the conditions of photosensitizer catalysis and illumination, a reaction is carried out for 1-4h at room temperature, and then separation and purification are carried out to obtain the product. The synthesis method of the aryl tertiary sulfonamide compound provided by the invention has the advantages of mild reaction conditions, simplicity and convenience in operation, short reaction time, no need of any transition metal catalysis and environmental friendliness.

Synthesis of sulfonamides promoted by alkyl iodide via a hypervalent iodine intermediate

Zhou, Zhongshi,He, Xuehan

supporting information, p. 280 - 284 (2019/11/16)

A new method for the preparation of sulfonamides from sodium sulfinates and amines is developed. A stoichiometric amount of m-chloroperbenzoic acid as oxidant and a catalytic amount of 1-iodopropane provides the corresponding sulfonamides in good yields under mild reaction conditions. In this protocol, 1-iodopropane is first oxidized by m-chloroperbenzoic acid into the corresponding hypervalent iodine intermediate iodosylpropane, which is highly unstable and decomposes at once to form hypoiodous acid. Then, the following reaction of the generated active hypoiodous acid with sodium sulfinates and amines results in the corresponding sulfonamides.

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