6435-78-5

Basic information

• Product Name: 1-[(4-methylphenyl)sulfonyl]pyrrolidine
• Synonyms: 1-[(4-methylphenyl)sulfonyl]pyrrolidine;TosPy
• CAS NO: 6435-78-5
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.31
• Mol File: 6435-78-5.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 352.9°Cat760mmHg
• Flash Point: 167.2°C
• Appearance: /
• Density: 1.229g/cm³
• CAS DataBase Reference: 1-[(4-methylphenyl)sulfonyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-methylphenyl)sulfonyl]pyrrolidine(6435-78-5)
• EPA Substance Registry System: 1-[(4-methylphenyl)sulfonyl]pyrrolidine(6435-78-5)

Safety Data

• Hazardous Substances Data: 6435-78-5(Hazardous Substances Data)

Usage

Description

1-[(4-methylphenyl)sulfonyl]pyrrolidine, also known as Lenalidomide, is a chemical compound that belongs to the class of immunomodulatory drugs. It is primarily used as a treatment for multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma. Lenalidomide works by stimulating the immune system to attack and destroy abnormal cells, and also has anti-inflammatory and anti-angiogenic properties. It is usually taken orally in the form of a capsule and is often used in combination with other medications for maximum effectiveness.

Uses

Used in Oncology:
Lenalidomide is used as an immunomodulatory drug for the treatment of multiple myeloma, myelodysplastic syndromes, and certain types of lymphoma. It enhances the immune system's ability to target and destroy abnormal cells, making it a valuable treatment option for these conditions.
Used in Combination Therapy:
Lenalidomide is often used in combination with other medications to maximize its therapeutic effects. This approach can help improve patient outcomes and increase the effectiveness of treatment for various cancers.
Used in Anti-inflammatory and Anti-angiogenic Treatments:
Due to its anti-inflammatory and anti-angiogenic properties, Lenalidomide can also be used in the treatment of conditions that involve inflammation and abnormal blood vessel growth. This makes it a versatile drug with potential applications in various medical fields.

Upstream product

• 123-75-1 pyrrolidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 110-52-1 1,4-dibromo-butane 
• 70-55-3 toluene-4-sulfonamide 
• 4724-56-5 1,4-ditosyloxybutane 
• 16851-72-2 1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole 
• 29281-83-2 4-methylbenzensulphonamide potassium salt 
• 104-15-4 toluene-4-sulfonic acid 
• 100649-38-5 N-(4-bromobutyl)-4-methylbenzenesulfonamide 
• 143590-75-4 N-<4-(Phenylseleno)butyl>-p-toluenesulfonamide 
• 78521-69-4 N-(3-hydroxybutyl)-4-methylbenzenesulfonamide 
• 941-55-9 4-toluenesulfonyl azide 
• 94191-33-0 1-<1-phenyl-2-(2-pyridyl)ethenyl>pyrrolidine 
• 1689-02-7 N-pyrrolidinesulfonyl chloride 

Downstream Products

• 86658-76-6 1-<(4-methyl-phenyl)sulfonyl>-2-methoxy-pyrrolidine 
• 949898-54-8 C₁₇H₁₈F₃N₃O₃S 
• 145472-45-3 1-tosylpyrrolidine-2-carbonitrile 
• 123-75-1 pyrrolidine 
• 145472-41-9 2-allyl-1-(tolylsulfonyl)pyrrolidine 
• 124920-12-3 2-ethyl-1-(toluene-4-sulfonyl)-pyrrolidine 
• 6435-79-6 2-methyl-1-[(4-methylphenyl)sulfonyl]-pyrrolidine 
• 1082606-29-8 C₁₁H₁₃⁽²⁾H₂NO₂S 
• 91411-17-5 dimethyl N-tosylpyrrolidine-2-phosphonate 
• 91411-15-3 2-(1-(4-methylbenzenesulfonyl)-2-pyrrolidinyl)-1-phenylethanone 
• 86658-78-8 N-tosyl tryptamine 
• 110-15-6 succinic acid 
• 138-41-0 4-(aminosulfonyl)-benzoic acid 

Relevant articles and documents

Method for preparing N-sulfonyl tetrahydropyrrole compound by using gold complex

The invention relates to a method for preparing an N-sulfonyl tetrahydropyrrole compound by using a gold complex, which comprises the following step of: reacting a sulfonamide compound and a tetrahydrofuran compound as raw materials with a gold complex containing an ortho-carborane Schiff base ligand as a catalyst at room temperature to obtain the N-sulfonyl tetrahydropyrrole compound. Compared with the prior art, the method has the advantages that the gold complex containing the ortho-carborane Schiff base ligand is adopted as the catalyst, the sulfonamide compound and the tetrahydrofuran compound can be catalyzed to react under the room temperature condition to prepare the N-sulfonyl tetrahydropyrrole compound, the usage amount of the catalyst is low, the reaction condition is mild, the reaction rate is high, the product yield is high, the substrate is high in universality, the raw materials are cheap and easy to obtain, and the method has a wide application prospect in industry.

Synthesis method of aryl tertiary sulfonamide compounds promoted by visible light

The invention provides a synthesis method of aryl tertiary sulfonamide compounds promoted by visible light. In a non-protonic solvent, N-benzyl tertiary amine and arylsulfonyl chloride are used as rawmaterials, under the conditions of photosensitizer catalysis and illumination, a reaction is carried out for 1-4h at room temperature, and then separation and purification are carried out to obtain the product. The synthesis method of the aryl tertiary sulfonamide compound provided by the invention has the advantages of mild reaction conditions, simplicity and convenience in operation, short reaction time, no need of any transition metal catalysis and environmental friendliness.

Synthesis of sulfonamides promoted by alkyl iodide via a hypervalent iodine intermediate

A new method for the preparation of sulfonamides from sodium sulfinates and amines is developed. A stoichiometric amount of m-chloroperbenzoic acid as oxidant and a catalytic amount of 1-iodopropane provides the corresponding sulfonamides in good yields under mild reaction conditions. In this protocol, 1-iodopropane is first oxidized by m-chloroperbenzoic acid into the corresponding hypervalent iodine intermediate iodosylpropane, which is highly unstable and decomposes at once to form hypoiodous acid. Then, the following reaction of the generated active hypoiodous acid with sodium sulfinates and amines results in the corresponding sulfonamides.