1006597-11-0

Upstream product

• 64-18-6 formic acid 
• 86398-96-1 5-amino-4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazole 
• 623584-51-0 C₁₁H₇Cl₂F₃N₄O 
• 77287-34-4 formamide 

Relevant academic research and scientific papers

A facile one-pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin- 4-ones

One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl3 has been developed. The structures of all the title compounds have been confirmed by IR, 1H-NMR, 13C-NMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.

Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization.