1006606-22-9Relevant academic research and scientific papers
Total synthesis of haouamine A: the indeno-tetrahydropyridine core
Burns, Noah Z.,Jessing, Mikkel,Baran, Phil S.
experimental part, p. 6600 - 6610 (2011/02/25)
A full account of synthetic efforts toward the indeno-tetrahydropyridine core of haouamine A is presented. Initial failed strategies led to the unexpected discovery of a mild abnormal Chichibabin pyridine synthesis and provided knowledge and inspiration f
Total synthesis of (±)-haouamine A
Baran, Phil S.,Burns, Noah Z.
, p. 3908 - 3909 (2007/10/03)
The first total synthesis of the highly complex and potent anticancer agent haouamine A is reported through an eight-step sequence. Brevity of the sequence and complete control of chemo-, position-, and stereoselectivity (both planar and axial chirality) were possible through the invention of chemistry specifically tailored for the problems at hand, namely a cascade annulation proceeding via a hitherto unknown chemical entity for the indeno-tetrahydropyridine ring system as well as a pyrone-assisted stitching of the daunting bent-aromatic ring. Copyright
