884320-39-2Relevant academic research and scientific papers
Total synthesis of (±)-haouamine A
Baran, Phil S.,Burns, Noah Z.
, p. 3908 - 3909 (2007/10/03)
The first total synthesis of the highly complex and potent anticancer agent haouamine A is reported through an eight-step sequence. Brevity of the sequence and complete control of chemo-, position-, and stereoselectivity (both planar and axial chirality) were possible through the invention of chemistry specifically tailored for the problems at hand, namely a cascade annulation proceeding via a hitherto unknown chemical entity for the indeno-tetrahydropyridine ring system as well as a pyrone-assisted stitching of the daunting bent-aromatic ring. Copyright
