100662-28-0

Upstream product

• 772-79-2 4-chlorophenylphosphorodichloridate 
• 81265-94-3 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl uridine 3'-p-chlorophenyl β-cyanoethyl phosphotriester 
• 81246-80-2 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine 
• 82444-93-7 Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester 
• 100638-42-4 Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 

Relevant academic research and scientific papers

Modified phosphotriester method for chemical synthesis of ribooligonucleotides. Part I. Synthesis of riboundecaadenylate and two fragments constituting the sequence of R-17 translation control signal

A modified phosphotriester method has been succesfully applied for the chemical synthesis of ribooligonucleotides.The starting material is a fully protected ribomononucleoside containing a 3'-phosphotriester group 5.The coupling reaction is performed usin

Efficient Synthesis of Oligoribonucleotides

The synthesis of a decaribonucleotide HOCGAUUCCGAGOHOH has been achieved by a phosphotriester method using nucleosides as a starting material.The key step for building trimer blocks was the use of 5'-dimethoxytrityl-2'-t-butyldimethylsilyl-ribonucleotide-3'(p-chlorophenyl,β-cyanoethyl)phosphates.The applied approach gave a rapid method of oligoribonucleotides preparation on a large scale in good yield.