82444-93-7

Upstream product

• 772-79-2 4-chlorophenylphosphorodichloridate 
• 81246-80-2 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine 
• 81265-94-3 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl uridine 3'-p-chlorophenyl β-cyanoethyl phosphotriester 

Downstream Products

• 100662-28-0 C₆₆H₇₉Cl₂N₅O₁₉P₂Si₂ 
• 100638-45-7 C₇₄H₈₄Cl₂N₈O₁₈P₂Si₂ 

Relevant academic research and scientific papers

Modified phosphotriester method for chemical synthesis of ribooligonucleotides. Part I. Synthesis of riboundecaadenylate and two fragments constituting the sequence of R-17 translation control signal

A modified phosphotriester method has been succesfully applied for the chemical synthesis of ribooligonucleotides.The starting material is a fully protected ribomononucleoside containing a 3'-phosphotriester group 5.The coupling reaction is performed usin

Synthesis of 4-(1,2,4-Triazol-1-yl)pyrimidin-2(1H)-one Ribonucleotide and Its Application in Synthesis of Oligoribonucleotides

5'-O-(Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)uridine (21) was converted to 4-(1,2,4-triazol-1-yl)-1-pyrimidin-2(1H)-one (20)

Efficient Synthesis of Oligoribonucleotides

The synthesis of a decaribonucleotide HOCGAUUCCGAGOHOH has been achieved by a phosphotriester method using nucleosides as a starting material.The key step for building trimer blocks was the use of 5'-dimethoxytrityl-2'-t-butyldimethylsilyl-ribonucleotide-3'(p-chlorophenyl,β-cyanoethyl)phosphates.The applied approach gave a rapid method of oligoribonucleotides preparation on a large scale in good yield.