1006689-32-2Relevant academic research and scientific papers
Toward a general synthesis of chlorins
O'Neal, William G.,Jacobi, Peter A.
, p. 1102 - 1108 (2008/09/21)
Recently, we described a new synthesis of C,D-ring symmetric chlorins 11, involving 2 + 2 condensation of bis-formyl-dihydrodipyrrins 9 with symmetrically substituted dipyrromethane diacids 10 (Method I). However, while versatile in many aspects, Method I
Studies in chlorin chemistry. 3. A practical synthesis of C,D-ring symmetric chlorins of potential utility in photodynamic therapy
O'Neal, William G.,Roberts, William P.,Ghosh, Indranath,Wang, Hui,Jacobi, Peter A.
, p. 3472 - 3480 (2007/10/03)
C,D-ring symmetric chlorins 8 were prepared in 47-85% yield, on scales up to several hundred milligrams, by condensation of appropriately substituted bis-formyldihydrodipyrrins 6 and dipyrromethane biscarboxylic acids 7 in 5% TFA/CH2Cl2/s
