1006689-73-1Relevant articles and documents
Synthesis and antiproliferative in-vitro activity of natural flavans and related compounds
Zhang, Liang,Zhang, Wei-Ge,Ma, En-Long,Wu, Lan,Bao, Kai,Wang, Xiao-Long,Wang, Yu-Ling,Song, Hong-Rui
, p. 650 - 655 (2007)
The total synthesis of natural flavan racemates (±) 1, (±) 2 and natural flavones 3, 4 had thus been achieved. A straightforward synthetic procedure of flavans via the Pd-C catalyzed hydrogenation/hydrogenolysis of corresponding flavones was developed. Furthermore, the antiproliferative activities of racemic flavans (±) 1, (±) 2, flavones 3, 4, and five synthetic intermediates toward human SGC-7901, BEL-7402, HeLa, and HL-60 cell lines in vitro were evaluated by MTT assay, and the racemic flavans (±) 1 were found to have significant antiproliferative activity against all four cell lines.