1006713-06-9Relevant academic research and scientific papers
An efficient method for the synthesis of nitropiperidones
Ruano, Jose Luis Garcia,De Haro, Teresa,Singh, Rajinder,Cid, M. Belen
, p. 1150 - 1153 (2008/09/18)
(Chemical Equation Presented) A three step efficient strategy for the synthesis of substituted 5-nitropiperidones in high de, employing Michael addition of N-p-tolylsulfinyl β-nitroamines to α,β-unsaturated esters, hydrolysis of the sulfinyl group, and cyclization of the resulting free amines, has been developed. A very simple experimental procedure involving mild conditions and only one chromatographic purification are the main features of the process.
