100675-76-1

Basic information

• Product Name: 5-iodo-3-phenyl-2.1-benzoisoxazole
• Synonyms: 5-iodo-3-phenyl-2.1-benzoisoxazole
• CAS NO: 100675-76-1
• Molecular Weight: 321.117
• Mol File: 100675-76-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-iodo-3-phenyl-2.1-benzoisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-iodo-3-phenyl-2.1-benzoisoxazole(100675-76-1)
• EPA Substance Registry System: 5-iodo-3-phenyl-2.1-benzoisoxazole(100675-76-1)

Safety Data

• Hazardous Substances Data: 100675-76-1(Hazardous Substances Data)

Usage

Chemical Class

Isoxazole derivative

Function

Potent and non-selective inhibitor of cyclic nucleotide phosphodiesterases (PDEs)

Enzyme Inhibition

Inhibits PDEs involved in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)

Scientific Research

Extensively used as a tool to investigate the role of PDEs in various physiological and pathological processes

Applications

Studied for potential therapeutic applications in treating conditions related to cAMP and cGMP signaling dysregulation

Potential Therapeutic Uses

Respiratory diseases, cardiovascular disorders, neurodegenerative diseases

Research Tools

Used in studies related to cell signaling, neurotransmission, and smooth muscle relaxation.

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 140-29-4 phenylacetonitrile 
• 51073-69-9 (2-amino-5-iodophenyl)(phenyl)methanone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Downstream Products

• 97423-34-2 8-Iodo-6-phenyl-1-(phenylmethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine 
• 97423-32-0 N-(2-Benzoyl-4-iodo-phenyl)-2-bromo-acetamide 
• 97423-33-1 1,3-dihydro-7-iodo-5-phenyl-2H-1,4-benzodiazepine-2-thione 
• 60114-64-9 7-iodo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 
• 51073-69-9 (2-amino-5-iodophenyl)(phenyl)methanone 

Relevant articles and documents

Synthesis of 3-phenylbenzo[c]isoxazoles by thermocyclization of 2-azidobenzophenones

3-Phenylbenzo[c]isoxazoles were synthesized by non-catalytic thermolysis of 2-azidobenzophenones in dry xylene with quantitative yields. The trace content of water in solvents reduces the yields of the reaction products. 2-Azidobenzoic acid esters are sta

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

Nucleophilic substitution of hydrogen in activated nitroarenes by phenylacetonitrile carbanion

General relations holding in nucleophilic substitution of hydrogen in para-substituted nitroarenes by phenylacetonitrile carbanion were analyzed in terms of the Klopman reactivity indices. Requirements to the substrate structure were determined, which restrict the scope of application of this method to synthesis of 2,1-benzisoxazole derivatives.