5-iodo-3-phenyl-2.1-benzoisoxazole

Base Information

• Chemical Name: 5-iodo-3-phenyl-2.1-benzoisoxazole
• CAS No.: 100675-76-1
• Molecular Formula: C₁₃H₈INO
• Molecular Weight: 321.117
• Mol file: 100675-76-1.mol

Synonyms:5-iodo-3-phenyl-2.1-benzoisoxazole

Chemical Property of 5-iodo-3-phenyl-2.1-benzoisoxazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Iodo-3-phenylbenzo[c]isoxazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-iodo-3-phenyl-2.1-benzoisoxazole

There total 5 articles about 5-iodo-3-phenyl-2.1-benzoisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C13H8IN3O → 5-iodo-3-phenyl-2.1-benzoisoxazole (100675-76-1)

Guidance literature:

In o-xylene; at 135 ℃; for 1h;

DOI:10.1007/s11172-019-2557-5

Reference yield: 96.0%

p-nitrobenzene iodide (636-98-6) + phenylacetonitrile (140-29-4) → 5-iodo-3-phenyl-2.1-benzoisoxazole (100675-76-1)

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

Reference yield:

(2-amino-5-iodophenyl)(phenyl)methanone (51073-69-9) → 5-iodo-3-phenyl-2.1-benzoisoxazole (100675-76-1)

Guidance literature:

With oxone; In water; acetonitrile; at 20 ℃; for 23h; chemoselective reaction; Green chemistry;

DOI:10.1055/s-0035-1561471

upstream raw materials:

p-nitrobenzene iodide

phenylacetonitrile

(2-amino-5-iodophenyl)(phenyl)methanone

(2-aminophenyl)(phenyl)methanone

Downstream raw materials:

8-Iodo-6-phenyl-1-(phenylmethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Refernces

• 1、 Orlov,Sokovikov,Kotov. "Nucleophilic replacement of hydrogen in para-substituted nitrobenzenes by phenylacetonitrile carbanion". . p. 100 - 103. Retrieved 2002.
• 2、 Chiarini, Marco,Del Vecchio, Luana,Marinelli, Fabio,Rossi, Leucio,Arcadi, Antonio. "Synthesis of 3-Substituted 2,1-Benzisoxazoles by the Oxidative Cyclization of 2-Aminoacylbenzenes with Oxone". . p. 3017 - 3030. Retrieved 2016/10/12.