1007-11-0

Basic information

• Product Name: 2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-
• Synonyms: 2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-;6-chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamine;6-chloro-N~4~,N~4~-dimethyl-2,4-pyrimidinediamine(SALTDATA: FREE);6-chloro-N~4~,N~4~-dimethyl-2,4-pyrimidinediamine;(2-amino-6-chloro-pyrimidin-4-yl)-dimethyl-amine;6-chloro-N',N'-dimethyl-pyrimidine-2,4-diamine;6-chloro-N',N'-dimethylpyrimidine-2,4-diamine
• CAS NO: 1007-11-0
• Molecular Formula: C₆H₉ClN₄
• Molecular Weight: 172.61546
• Mol File: 1007-11-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 384.4°Cat760mmHg
• Flash Point: 186.3°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 4.1E-06mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-(1007-11-0)
• EPA Substance Registry System: 2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-dimethyl-(1007-11-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1007-11-0(Hazardous Substances Data)

Usage

General Description

2,4-pyrimidinediamine, 6-chloro-N^4^,N^4^-dimethyl- is a chemical compound with the molecular formula C6H8ClN4. It is an organic compound that consists of a pyrimidine ring with a chlorine atom at the 6-position and dimethyl groups at the N^4^ positions. This chemical is commonly used in the production of pharmaceuticals, such as antiviral and antibacterial medications. It is also used as a research reagent and in the synthesis of various organic compounds. However, 2,4-pyrimidinediamine, 6-chloro-N^4^,N^4^-dimethyl- should be handled and stored with care, as it can be hazardous if not used properly.

InChI:InChI=1/C6H9ClN4/c1-11(2)5-3-4(7)9-6(8)10-5/h3H,1-2H3,(H2,8,9,10)

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 1271022-21-9 C₁₃H₁₂FN₅ 

Relevant articles and documents

Barriers to Rotation of the Dimethylamino Group in Some 2-Amino-4-(N,N-dimethylamino)pyrimidines

The free energy of activation for rotation about the exocyclic C-N bond of the dimethylamino group of some 6-substituted 2-amino-4-(N,N-dimethylamino)pyrimidines has been determined using 1H NMR line shape analysis.The results are discussed in terms of the relative electron-withdrawing and electron-releasing effects of the substituents.

CHEMICAL COMPOUNDS

The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.