100710-37-0

Usage

Uses

Used in Pharmaceutical Synthesis:
2-NAPHTHALEN-2-YL-PYRROLIDINE is used as a key building block for the synthesis of various pharmaceuticals and organic compounds. Its structural properties make it a valuable component in the development of new drugs and medicinal agents.
Used in Organic Electronics:
Due to its unique structural properties, 2-NAPHTHALEN-2-YL-PYRROLIDINE is used in the field of organic electronics, where it may contribute to the development of novel electronic materials and devices.
Used in Materials Science:
In the realm of materials science, 2-NAPHTHALEN-2-YL-PYRROLIDINE is utilized for its potential to enhance or create new materials with specific properties, taking advantage of its chemical and physical characteristics.
Used in Medicinal Applications:
2-NAPHTHALEN-2-YL-PYRROLIDINE is used as a pharmacological agent for its anticonvulsant and antinociceptive properties, indicating its potential use in the treatment of conditions related to seizures and pain management.

Upstream product

• 52044-99-2 4-(naphthalen-2-yl)-4-oxobutanenitrile 
• 123-75-1 pyrrolidine 
• 4541-70-2 2-naphthyllithium 

Relevant academic research and scientific papers

CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE

The present disclosure discusses (i) a compound having a chemical formula according to Formula (I), or its enantiomer; and (ii) a compound that is reactive with a hydride to produce a compound having a chemical formula according to Formula (I), or its enantiomer. Formula (I) is: Formula (I) where R1 and R2 are H, optionally substituted C1-C3 alkyl, or linked together to form an optionally substituted C3 or C4 alkyl group; R3 and R3' are H; R4 and R4' are the same, and are optionally substituted C1-C6 alkyl; and R5 and R5' are the same, and are optionally substituted aryl or heteroaryl. In some examples, R4 and R5 are linked, and R4' and R5' are linked, where both linking groups are the same. The present disclosure also discusses methods of asymmetric reduction of an imine, and methods of forming the catalysts and pre-catalysts.

Direct α-C-H bond functionalization of unprotected cyclic amines

Cyclic amines are ubiquitous core structures of bioactive natural products and pharmaceutical drugs. Although the site-selective abstraction of C-H bonds is an attractive strategy for preparing valuable functionalized amines from their readily available parent heterocycles, this approach has largely been limited to substrates that require protection of the amine nitrogen atom. In addition, most methods rely on transition metals and are incompatible with the presence of amine N-H bonds. Here we introduce a protecting-group-free approach for the α-functionalization of cyclic secondary amines. An operationally simple one-pot procedure generates products via a process that involves intermolecular hydride transfer to generate an imine intermediate that is subsequently captured by a nucleophile, such as an alkyl or aryl lithium compound. Reactions are regioselective and stereospecific and enable the rapid preparation of bioactive amines, as exemplified by the facile synthesis of anabasine and (-)-solenopsin A.