100710-88-1

Upstream product

• 31749-10-7 (3,4-dimethoxyphenyl)(pyridin-2-yl)methanol 
• 5005-41-4 3,4-dimethoxyphenyl-(2-pyridyl)acetonitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 100-70-9 2-Cyanopyridine 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 1699-51-0 laudanosine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 33455-70-8 N-methyl-2-(3,4-dimethoxybenzyl)piperidine 
• 108958-45-8 N-n.propyl-2-(3,4-dimethoxybenzyl)piperidine 
• 108958-39-0 N-acetyl-2-(3,4-dimethoxybenzyl)piperidine 
• 108958-41-4 N-propionyl-2-(3,4-dimethoxybenzyl)piperidine 
• 108997-38-2 N-ethoxycarbonyl-2-(3,4-dimethoxybenzyl)piperidine 
• 108958-44-7 N-ethyl-2-(3,4-dimethoxybenzyl)piperidine 
• 6495-96-1 8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizine 
• 109728-33-8 1-acetonyl-2-veratryl-pyridinium; iodide 
• 102458-70-8 2-(3,4-dimethoxybenzyl)piperidine 
• 112578-50-4 1-phenacyl-2-veratryl-pyridinium; bromide 

Relevant academic research and scientific papers

Transition-Metal-Free Decarboxylative Photoredox Coupling of Carboxylic Acids and Alcohols with Aromatic Nitriles

A transition-metal-free protocol for the redox-neutral light-induced decarboxylative coupling of carboxylic acids with (hetero)aromatic nitriles at ambient temperature is presented. A broad scope of acids and nitriles is accepted, and alcohols can be coupled in a similar fashion through their oxalate half esters. Various inexpensive sources of UV light and even sunlight can be used to achieve this C-C bond formation proceeding through a free radical mechanism.

Light-Induced Alkylation of (Hetero)aromatic Nitriles in a Transition-Metal-Free C-C-Bond Metathesis

A light-induced C-C-σ-bond metathesis was achieved through transition-metal-free activation of an unstrained C(sp3)-C(sp3)-σ-bond in 1-benzyl-1,2,3,4-tetrahydroisoquinolines. A photoredox-mediated single-electron oxidation of these precursor amines yield radical cations which undergo a homolytic cleavage of a C(sp3)-C(sp3)-σ-bond rather than the well-known α-C-H-scission. The resulting carbon-centered radicals are used in the ipso-substitution of (hetero)aromatic nitriles proceeding through another single-electron transfer-mediated C-C-bond cleavage and formation.