100712-22-9

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 100-63-0 phenylhydrazine 
• 622-95-7 4-chlorobenzyl bromide 
• 530740-34-2 2-(4-chloro-benzylamino)-isoindole-1,3-dione 
• 34403-64-0 N-(p-chlorobenzylideneamino)phthalimide 
• 530740-40-0 2-[(4-chloro-benzyl)-phenyl-amino]-isoindole-1,3-dione 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 113950-43-9 5-(4-chloro-benzyl)-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 123336-31-2 furfural-[(4-chloro-benzyl)-phenyl-hydrazone] 
• 47454-09-1 1-morpholin-4-yl-propan-2-one (4-chloro-benzyl)-phenyl-hydrazone 
• 13993-13-0 1-(4-chloro-benzyl)-2-methyl-3-morpholin-4-yl-indole 

Relevant academic research and scientific papers

Reductive Hydrazination with Trichlorosilane: A Method for the Preparation of 1,1-Disubstituted Hydrazines

A straightforward and facile method has been developed to prepare 1,1-disubstituted hydrazines via Lewis base promoted direct reductive hydrazination. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively, various ketones and aldehydes could react with phenylhdrazines to prepare 1,1-disubstituted hydrazines with good to high yields.

2,3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

The protein-protein interaction of p53 and MDM2/X is a promising non genotoxic anticancer target. A rapid and efficient methodology was developed to synthesize the 2,3′-bis(1′H-indole) heterocyclic scaffold 2 as ester, acid and amide derivatives. Their binding affinity with MDM2 was evaluated using both fluorescence polarization (FP) assay and HSQC experiments, indicating good inhibition and a perfect starting point for further optimizations.

A convenient synthesis of 1-alkyl-1-phenylhydrazines from N-aminophthalimide

N-Alkylaminophthalimides were synthesized by condensation of N-aminophthalimide with aldehydes, and subsequent reduction of the intermediate with pyridine-borane in acetic acid. N-Phenylation and removal of the phthalimide group gave 1-alkyl-1-phenylhydrazines in high yield.