1007125-06-5Relevant academic research and scientific papers
RNAs Containing Carbocyclic Ribonucleotides
Akabane-Nakata, Masaaki,Chickering, Tyler,Harp, Joel M.,Schlegel, Mark K.,Matsuda, Shigeo,Egli, Martin,Manoharan, Muthiah
supporting information, p. 525 - 530 (2022/01/12)
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Crystall
CARBOCYCLIC NUCLEOSIDE ANALOGUE
-
Page/Page column 25-26, (2020/12/30)
The present invention relates to novel hydrolytically stable carbocyclic 5-aza-2-deoxycytidine and carbocyclic 5-aza-cytidine compounds and prodrugs thereof as hypomethylating agents.
Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
-
, (2016/06/01)
The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) from a readily available starting material (Vince lactam) in fourteen steps. An efficient and practical methodology for stereospecifi
Stereoselective synthesis of 2′-fluoro-6′-methylene carbocyclic adenosine via Vince lactam
Singh, Uma S.,Mishra, Ram C.,Shankar, Ravi,Chu, Chung K.
, p. 3917 - 3923 (2014/05/20)
2′-Fluoro-6′-methylene carbocyclic adenosine (FMCA) is a potent and selective inhibitor of wild type as well as drug-resistant hepatitis B virus (HBV) mutants. FMCA demonstrated excellent anti-HBV activity against both adefovir-resistant and lamivudine-re
Heteroaryl compounds useful as inhibitors of E1 activating enzymes
-
Page/Page column 91, (2008/06/13)
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
