1007125-06-5Relevant articles and documents
RNAs Containing Carbocyclic Ribonucleotides
Akabane-Nakata, Masaaki,Chickering, Tyler,Harp, Joel M.,Schlegel, Mark K.,Matsuda, Shigeo,Egli, Martin,Manoharan, Muthiah
supporting information, p. 525 - 530 (2022/01/12)
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Crystall
Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
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, (2016/06/01)
The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) from a readily available starting material (Vince lactam) in fourteen steps. An efficient and practical methodology for stereospecifi
Heteroaryl compounds useful as inhibitors of E1 activating enzymes
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Page/Page column 91, (2008/06/13)
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.