100718-84-1Relevant academic research and scientific papers
Nenitzescu Synthesis of 5-Hydroxyindoles with Zinc, Iron and Magnesium Salts in Cyclopentyl Methyl Ether
Azzena, Ugo,Beccu, Andrea,Carboni, Silvia,Carraro, Massimo,De Luca, Lidia,Gaspa, Silvia,Livesi, Marco,Pira, Giovanni Michele,Pisano, Luisa,R?mer, Melina,Satta, Giuseppe,Solinas, Angelo,Usala, Elena
, p. 5835 - 5842 (2021/11/17)
In this work, mild Lewis acids and low environmental impact solvents were investigated for Nenitzescu synthesis. Cyclopentyl methyl ether can be used at room temperature in substitution of halogenated solvents with zinc, iron and magnesium salts as homogeneous catalysts to give 5-hydroxyindoles in fair to good yields. The reaction features a straightforward workup and excellent solvent recycle.
The role of a Lewis acid in the Nenitzescu indole synthesis
Velezheva, Valeriya S.,Sokolov, Andrey I.,Kornienko, Albert G.,Lyssenko, Konstantin A.,Nelyubina, Yulia V.,Godovikov, Ivan A.,Peregudov, Alexander S.,Mironov, Andrey F.
scheme or table, p. 7106 - 7109 (2009/04/10)
A highly efficient Lewis acid-catalyzed method for the Nenitzescu synthesis of 5-hydroxyindoles with a range of substituents at N-1 and C-3 and symmetric 5,5′-dihydroxydiindoles has been developed. The amount of the catalyst (10-100 mol %) required depend
