100719-20-8

Usage

Uses

Used in Organic Synthesis:
2-[(2-hydroxyphenylamino)methylene]malonic acid diethyl ester is utilized as a reagent in organic synthesis, particularly for the preparation of heterocyclic compounds and pharmaceutical intermediates. Its ability to form heterocyclic structures makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[(2-hydroxyphenylamino)methylene]malonic acid diethyl ester serves as a key intermediate in the development of various drugs. Its unique structure allows for the creation of new pharmaceutical compounds with potential therapeutic properties.
Used in Dye and Pigment Production:
2-[(2-hydroxyphenylamino)methylene]malonic acid diethyl ester is employed in the production of dyes and pigments due to its ability to impart color to various materials. Its chemical properties make it suitable for use in creating a wide range of colors for different applications.
Used in Other Organic Chemicals Production:
Beyond its applications in organic synthesis, pharmaceuticals, dyes, and pigments, 2-[(2-hydroxyphenylamino)methylene]malonic acid diethyl ester also finds use in the production of other organic chemicals. Its versatility and reactivity contribute to the development of new chemical compounds for various industrial applications.

Upstream product

• 95-55-6 2-amino-phenol 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 431911-73-8 β,β-bis(ethoxycarbonyl)acrylic acid 

Downstream Products

• 6358-23-2 2-hydroxy-2',4'-dinitrodiphenylamine 
• 103976-26-7 2-[(2-ethoxyphenylamino)methylene]malonic acid diethyl ester 
• 64-17-5 ethanol 
• 27333-37-5 4,8-dihydroxy-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Hydrogen bonding due to regioisomerism and its effect on the supramolecular architecture of diethyl 2-[(2/4-hydroxyanilino)methylidene]malonates

Diethyl 2-[(2-hydroxyanilino)methylidene]malonate, (I), and diethyl 2-[(4-hydroxyanilino)methylidene]malonate, (II), both C14H 17NO5, crystallize in centrosymmetric orthorhombic and monoclinic crystal systems, respectively. Compound

2,2-Bis(ethoxycarbonyl)vinyl (BECV) as a versatile amine protecting group for selective functional-group transformations

A 2,2-Bis(ethoxycarbonyl) vinyl- (BECV) group was used for the selective protection of amines at room temperature in the presence of potentially interfering functional groups such as OH, SH, COOH as well as other NH 2 groups. Several functional group transformations such as esterification, O-alkylation, O-acylation, N-alkylation, N-acylation, S-alkylation can selectively be carried out in the presence of the BECV group. The selective deprotection of the BECV group was achieved in a short time using ethylenediamine at room temperature while several other functional groups such as benzoate, aliphatic esters, amides and ethers remain intact. The BECV group shows orthogonal stability against the common protecting groups such as Fmoc, Cbz and Boc.

Efficient synthesis of heterocyclic compounds using ethenetricarboxylic acid diesters

Ethenetricarboxylic acid diester 1a is a useful compound bearing two reactive sites, a CO2H group and a Michael acceptor. Reactions of 1a and reagents with oxygen and nitrogen nucleophilic moieties have been examined. The reaction of 1a with 2-

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.