100724-25-2

Basic information

• Product Name: N'-(furan-2-ylmethylene)-4-methoxybenzohydrazide
• Synonyms: N'-(furan-2-ylmethylene)-4-methoxybenzohydrazide
• CAS NO: 100724-25-2
• Molecular Weight: 244.25
• Mol File: 100724-25-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N'-(furan-2-ylmethylene)-4-methoxybenzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(furan-2-ylmethylene)-4-methoxybenzohydrazide(100724-25-2)
• EPA Substance Registry System: N'-(furan-2-ylmethylene)-4-methoxybenzohydrazide(100724-25-2)

Safety Data

• Hazardous Substances Data: 100724-25-2(Hazardous Substances Data)

Upstream product

• 121-98-2 methyl 4-methoxybenzoate 
• 98-01-1 furfural 
• 3290-99-1 4-methoxybenzoic acid hydrazide 

Downstream Products

• 37584-92-2 2-(furan-2-yl)-5-(4-methoxy-phenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Analogs of Nitrofuran Antibiotics to Combat Resistance

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Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity

A series of 4-methoxybenzoylhydrazones 1-30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 M, when compared to a rutin standard (IC50 = 294.46 1.50 M). Compounds 1 (IC50 = 216.52 4.2 M), 3 (IC50 = 289.58 2.64 M), 6 (IC50 = 227.75 0.53 M), 7 (IC50 = 242.53 6.1) and 11 (IC50 = 287.79 1.59) all showed more activity that the standard, and these compounds have the potential to serve as possible leads for drugs to inhibit protein glycation in diabetic patients. A preliminary SAR study was performed.