100728-08-3Relevant academic research and scientific papers
3-AMINOINDAZOLES
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Page/Page column 73, (2008/06/13)
Novel 3-aminoindazoles of formula (I) are SGK-inhibitors and can be used for treating SGK-related diseases and illnesses such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, and generally any type of fibroses and inflammatory processes.
6-Heteroaryl-pyrazolo[3,4-b]pyridines: Potent and selective inhibitors of Glycogen Synthase Kinase-3 (GSK-3)
Witherington, Jason,Bordas, Vincent,Gaiba, Alessandra,Naylor, Antoinette,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Takle, Andrew K.,Ward, Robert W.
, p. 3059 - 3062 (2007/10/03)
A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependant Kinase-2 (CDK-2).
