5435-92-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-phenylbenzonitrile is used as an intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the production of drugs, contributing to the development of new medications and therapies.
Used in Agrochemical Industry:
2-Chloro-4-phenylbenzonitrile is also utilized as an intermediate in the synthesis of agrochemicals. It aids in the development of pesticides, herbicides, and other agricultural products to enhance crop protection and yield.
Used in Dye and Pigment Production:
2-Chloro-4-phenylbenzonitrile serves as a building block for the production of dyes and pigments. It is instrumental in creating a wide range of colors used in various industries, including textiles, plastics, and printing.
Used in Fine Chemicals Industry:
Furthermore, 2-Chloro-4-phenylbenzonitrile is used in the production of fine chemicals, which are high-purity chemicals employed in research, chemical synthesis, and other specialized applications. Its versatility makes it valuable in various chemical processes and reactions.

InChI:InChI=1/C13H8ClN/c14-13-8-11(6-7-12(13)9-15)10-4-2-1-3-5-10/h1-8H

Upstream product

• 21424-83-9 3-chloro-4-methoxy-1,1'-biphenyl 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 28557-00-8 phenylzinc chloride 
• 3336-16-1 2-chloro-4-hydroxybenzonitrile 
• 7285-66-7 3-chlorobiphenyl-4-amine 
• 71-43-2 benzene 

Downstream Products

• 100728-08-3 6-phenyl-1⁽²⁾H-indazol-3-ylamine 
• 5728-40-5 3-chloro-[1,1'-biphenyl]-4-carboxylic acid 

Relevant academic research and scientific papers

Site-Selective, Modular Diversification of Polyhalogenated Aryl Fluorosulfates (ArOSO2F) Enabled by an Air-Stable PdI Dimer

Since 2014, the interest in aryl fluorosulfates (ArOSO2F) as well as their implementation in powerful applications has continuously grown. In this context, the enabling capability of ArOSO2F will strongly depend on the substitution pattern of the arene, which ultimately dictates its overall function as drug candidate, material, or bio-linker. This report showcases the modular, substrate-independent, and fully predictable, selective functionalization of polysubstituted arenes bearing C?OSO2F, C?Br, and C?Cl sites, which makes it possible to diversify the arene in the presence of OSO2F or utilize OSO2F as a triflate surrogate. Sequential and triply selective arylations and alkylations were realized within minutes at room temperature, using a single and air-stable PdI dimer.

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

Modular Functionalization of Arenes in a Triply Selective Sequence: Rapid C(sp2) and C(sp3) Coupling of C?Br, C?OTf, and C?Cl Bonds Enabled by a Single Palladium(I) Dimer

Full control over multiple competing coupling sites would enable straightforward access to densely functionalized compound libraries. Historically, the site selection in Pd0-catalyzed functionalizations of poly(pseudo)halogenated arenes has been unpredictable, being dependent on the employed catalyst, the reaction conditions, and the substrate itself. Building on our previous report of C?Br-selective functionalization in the presence of C?OTf and C?Cl bonds, we herein complete the sequence and demonstrate the first general arylations and alkylations of C?OTf bonds (in I dimer. This allowed the realization of the first general and triply selective sequential C?C coupling (in 2D and 3D space) of C?Br followed by C?OTf and then C?Cl bonds.