10073-94-6

Upstream product

• 4005-02-1 ethyl 4-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoate 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 118-92-3 anthranilic acid 
• 4005-05-4 4-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoic acid 
• 863988-62-9 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoyl chloride 

Downstream Products

• 139447-36-2 3-[4-(5-Mercapto-4-phenyl-4H-[1,2,4]triazol-3-yl)-phenyl]-2-methyl-3H-quinazolin-4-one 
• 93574-08-4 C₂₃H₁₉N₅O₂S 
• 139447-38-4 3-{4-[4-(4-Bromo-phenyl)-5-mercapto-4H-[1,2,4]triazol-3-yl]-phenyl}-2-methyl-3H-quinazolin-4-one 
• 93574-70-0 C₂₁H₂₃N₅O₂S 
• 1898-06-2 3-amino-2-methyl-4-oxoquinazoline 
• 5351-17-7 4-aminobenzohydrazide 
• 1386858-33-8 2-methyl-3-(4-(3-phenyl-5-p-tolyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)quinazolin-4(3H)-one 
• 1386858-34-9 2-methyl-3-(4-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)quinazolin-4(3H)-one 
• 1386858-35-0 3-(4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)-2-methylquinazolin-4(3H)-one 
• 1386858-36-1 3-(4-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)-2-methylquinazolin-4(3H)-one 
• 1386858-37-2 3-(4-(5-(4-hydroxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)-2-methylquinazolin-4(3H)-one 
• 1386858-38-3 3-(4-(5-(4-(dimethylamino)phenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl)-2-methylquinazolin-4(3H)-one 
• 1449658-22-3 4-(2-methyl-4-oxo-(3H)quinazolin-3-yl)-benzoic acid (4-[1,3]dioxolan-2-yl-benzylidene) hydrazide 
• 1449658-28-9 4-(2-methyl-4-oxo-3H-quinazolin-3-yl)-benzoic acid (4-formyl-benzylidene) hydrazide 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of novel quinazolin-4(3H)-one derived pyrazole analogs

Eighteen novel 6,8-(dibromo/unsubstituted)-2-(methyl/phenyl)-3-(4-(5- (substitutedphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbonyl)phenyl) -quinazolin-4(3H)-ones 4a-4r were designed and synthesized in good yield. Antiepileptic screening of the title compounds was performed using MES and scPTZ seizures tests while the neurotoxicity was determined by rotorod test. In the preliminary screening, compounds 4d, 4e, 4p, 4q, and 4r were found active in MES model, while 4a, 4d, 4f, 4m, and 4p showed significant antiepileptic activity in scPTZ model. Further, all these eight compounds were administered to rats and compounds 4e, 4p, and 4q showed better activity than Phenytoin in oral route. Among these compounds 4p revealed protection in MES after i.p. administration at a dose of 30 mg/kg (0.5 h) and 100 mg/kg (4 h). The compound 4p also provided protection in the scPTZ at a dose of 100 mg/kg (0.5 h) and 300 mg/kg (4 h).

Heterocyclic synthesis: A convenient route to some 2-mercepto 1,3,4-oxadiazole and green chemistry microwave-induced one-pot synthesis of 2-aryl 1,3,4-oxadiazole in quinazolone and their antibacterial and antifungal activity

Several 6-substituted-3-[(5-mercepto-1,3,4-oxadiazol-2-yl)methyl]-2- substituted quinazolin-4(3H)-one or 6-substituted-3-[4-(5-mercepto-1,3,4- oxadiazol-2-yl)phenyl]-2-substituedquinazolin-4(3H)-one 2(a-l) and 6-substituted-3-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-2-substitutedquinazolin- 4(3H)-one or 6-substituted-3-[4-(5-phenyl-1,3,4-oxadiazol-2-yl) phenyl]-2-substitutedquinazolin-4(3H)-one 3(a-l) were synthesized using conventional and microwave techniques respectively and were screened for antibacterial and antifungal activity.

Synthesis and antimicrobial activity of some pyrazoline derivatives of 4(3H)-quinazolinones

The present communication describes the synthesis and antimicrobial activity of some new 6,8-disubstituted-2-(phenyl/methyl)-3-|4-(3-methyl-5-pyrazolinon-1-yl)carbonyl) phenyl/benzyl/methyl|-4(3H)-qainazolinones.

Synthesis and antimicrobial activity of noval quinazolone derivatives

Three novel series of 4-oxoquinazoline derivatives were prepared and evaluated as potential antimicrobial agents. Evaluation of the antimicrobial activity of a variety of 4-substituted-1-thiosemicarbazides, 3,4-disubstituted thiazolines, and 3-substituted-5-thiazolidones reveals that the majority possess significant in vitro activity against Gram-positive organisms. Some derivatives also exhibited antifungal activity.