100731-12-2Relevant academic research and scientific papers
Models for thyroxine: Aromatic iodine-assisted self-assemblies
Barceló-Oliver, Miquel,Terrón, Angel,García-Raso, Angel,Molins, Elies
, p. 1417 - 1426 (2007)
Trying to understand the different recognition factors between thyroxine and its binding proteins, the chemistry of the ternary complexes between copper and o-iodobenzoylglycine (I-hip) [or o-iodobenzoylglycilglycine (BIGG)] as simple thyroxine models were studied with 2,2′-bipyridyl as secondary ligand. Two new compounds have been synthesized and structurally characterized: [Cu(I-hip)(bpy)2]+(I-) · 1.5H2O and [Cu(BIGG)(bpy)2]+(I-) · 4H2O. These compounds and other previously reported by us offer interesting recognition patterns that could have biological relevance: iodine-iodine short interactions, iodine-hydrogen(aliphatic or aromatic) interactions, iodine-metal bonds, iodine-π interactions (like C-H?π), and aromatic self-assemblies assisted by iodine atoms. These patterns can be coupled in a synergistic manner, producing, for instance, a new C-I?π?π?I-C cluster pattern.
