1007313-83-8Relevant academic research and scientific papers
Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
Wang, Cuihua,Barluenga, Sofia,Koripelly, Girish K.,Fontaine, Jean-Gonzague,Chen, Ruihong,Yu, Jin-Chen,Shen, Xiaodong,Chabala, John C.,Heck, James V.,Rubenstein, Allan,Winssinger, Nicolas
supporting information; experimental part, p. 3836 - 3840 (2010/04/05)
Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate for
MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90
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Page/Page column 114; 149-150, (2010/11/30)
Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.
