1007346-78-2Relevant academic research and scientific papers
Guaiane sesquiterpene lactones and amino acid-sesquiterpene lactone conjugates from the aerial parts of Saussurea pulchella
Min, Cheol Yang,Sang, Un Choi,Wahn, Soo Choi,Sun, Yeou Kim,Kang, Ro Lee
, p. 678 - 683 (2008)
Two new guaiane sesquiterpene lactones (1 and 2) and seven new amino acid-sesquiterpene lactone conjugates (3-9), together with six known sesquiterpene lactones (10-15), were isolated from the methanol extract of the aerial parts of Saussurea pulchella. Their structures were determined on the basis of spectroscopic and chemical methods to be 8α-O-(3′-hydroxy- 3′-methylbutyryl)desacylcynaropicrin (1), 8α-O-(2′, 3′-dihydroxyisobutyryl)l 11β,13-dihydrodesacylcynaropicrin (2), and pulchellamines A, B, C, D, E, F, and G (3-9). The structures of the new amino acid-sesquiterpene lactone conjugates, pulchellamines A, B, C, D, E, F, and G (3-9), were confirmed by synthesis. The isolated compounds were evaluated for cytotoxic activity against four human tumor cell lines. Compounds 11 and 12 exhibited cytotoxicity against skin melanoma (SK-MEL-2) and ovary malignant ascites (SK-OV-3) human tumor cell lines with ED50 values of 1.53 and 4.07 μM, and 2.49 and 7.42 μM, respectively.
