1007374-85-7Relevant academic research and scientific papers
Versatile and fluoride-free cyanation of alkyl halides and sulfonates with trimethylsilyl cyanide
Yabe, Osamu,Mizufune, Hideya,Ikemoto, Tomomi
, p. 1291 - 1294 (2009)
Cyanation of biphenyl-4-ylmethyl methanesulfonate with trimethylsilyl cyanide using fluoride-free inorganic salts, such as Cs2CO 3, K2CO3, and LiOH·H2O, as additives in MeCN quantitatively gave biphenyl-4-ylacetonitrile. This methodology was applied to various alkyl halides to give the corresponding nitrile compounds in good to excellent yields. Of note, 4-(hydroxymethyl) benzyliodide O-protected by the silyl group was converted into phenylacetonitrile derivative in 99% yield without desilylation. Georg Thieme Verlag Stuttgart.
